1. Anti-infection
  2. Parasite
  3. Antimalarial agent 61

Antimalarial agent 61 是一种具有抗疟剂。Antimalarial agent 61 会破坏恶性疟原虫无性血液期滋养体的血红蛋白分解过程。Antimalarial agent 61 对 Chloroquine (HY-17589A) 敏感型恶性疟原虫具有抗疟原虫活性。Antimalarial agent 61 可用于疟疾相关研究。

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Antimalarial agent 61

Antimalarial agent 61 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antimalarial agent 61 is an antimalarial agent. Antimalarial agent 61 disrupts hemoglobin breakdown in Plasmodium falciparum asexual blood stage trophozoites. Antimalarial agent 61 exerts antiplasmodial activity against Chloroquine (HY-17589A)-sensitive Plasmodium falciparum parasites. Antimalarial agent 61 can be used for the research of malaria[1].

IC50 & Target[1]

Plasmodium falciparum sporozoites

 

体外研究
(In Vitro)

Antimalarial agent 61 (Compound 33) 可强效抑制 Plasmodium falciparum 3D7 株的增殖,其 IC50 为 0.08 μM;同时该药物对 HeLa 细胞的细胞毒性极低 (IC50 >20 μM)[1]
Antimalarial agent 61 (0.8 μM;2.5 小时) 可破坏 Plasmodium falciparum 3D7 滋养体中的血红蛋白分解代谢,并呈现出独特的代谢谱,提示存在额外的作用机制通路[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.67

Formula

C34H36N4O4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antimalarial agent 61
目录号:
HY-183238
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