2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Calcium Channel
  4. AWD 122-60

AWD 122-60 是一种钾通道阻滞剂和钙敏化剂，对小鼠骨骼肌 ATP 敏感性钾 (KATP) 通道的 IC50 值分别为 11 μM 和 29 μM。AWD 122-60 发挥强效正性肌力活性。AWD 122-60 在体内具有抗心律失常活性，并且在体外可延长心肌不应期。AWD 122-60 可用于心律失常的相关研究。

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AWD 122-60

AWD 122-60 Chemical Structure

CAS No. : 108610-89-5

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AWD 122-60 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias[1][2].

IC50 & Target[1]

KATP

11 or 29 μM (IC50)

体外研究
(In Vitro)

AWD 122-60 发挥强效正性肌力活性和负性变时效应[1]。
AWD 122-60 (1-1000 μM) 可逆性抑制分离自成年小鼠趾短屈肌骨骼肌纤维的内面向外式膜片钳标本中的 KATP 通道[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AWD 122-60 相关抗体:
体内研究
(In Vivo)

AWD 122-60 在体内具有抗心律失常活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

309.42

Formula

C18H23N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AWD 122-60 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AWD 122-60108610-89-5Potassium ChannelCalcium ChannelKcsACa2+ channelsCa channelspotassium channel blockerantiarrhythmic agentacute myocardial ischemianegative chronotropic agentpositive inotropic agentcalcium sensitizermouse skeletal muscle ATP-sensitive potassium (K(ATP)) channelmouse flexor digitorum brevis skeletal muscle fibresmyocardial refractory period prolongerarrhythmiaInhibitorinhibitorinhibit

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产品名称：
AWD 122-60
目录号：
HY-165486
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