2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ aggregation-IN-4

Aβ aggregation-IN-4 能够减轻 β-淀粉样蛋白 (Aβ) 的神经毒性，并显著降低 Aβ 寡聚体复合物 (Aβ-OCs) 的水平。Aβ aggregation-IN-4 不降低 Aβ 的水平。Aβ aggregation-IN-4 可减弱 Aβ 寡聚化，并预防寡聚体诱导的原代皮层神经元死亡。Aβ aggregation-IN-4 可用于阿尔茨海默病 (AD) 的研究。

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Aβ aggregation-IN-4

Aβ aggregation-IN-4 Chemical Structure

CAS No. : 603113-07-1

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Aβ aggregation-IN-4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs). Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ). Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD)[1].

体外研究
(In Vitro)

Aβ aggregation-IN-4 (0-2 μM，24-48 小时) 能保护 MC65 细胞，并以剂量依赖的方式降低 MC65 细胞内 Aβ 寡聚体的水平 (EC50=0.15 μM)[1]。
Aβ aggregation-IN-4 (0-14 小时) 是一种细胞渗透性化合物。[14C]Amyloid-β-IN-4 在 2 小时内即可在 MC65 细胞内达到饱和浓度，并能快速进入细胞[1]。
Aβ aggregation-IN-4 与 Aβ40 和 Aβ42 的结合亲和力 (Kd) 分别为 5.05 nM 和 269 nM[1]。
Aβ aggregation-IN-4 (10 μM，24 小时) 能显著降低 Aβ40 和 Aβ42 寡聚体的密度[1]。
Aβ aggregation-IN-4 (50 nM，48 小时) 能阻断新生小鼠皮层原代神经元培养物中细胞外 Aβ 寡聚体的神经毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ aggregation-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: Primary cultures of cortical neurons from newborn mice
Concentration: 50 nM
Incubation Time: 48 h
Result: Blocked the neurotoxicity of extracellular Aβ oligomers in primary cultures of cortical neurons from newborn mice.
分子量

393.44

Formula

C21H23N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ aggregation-IN-4 相关分类

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Keywords:

Aβ aggregation-IN-4603113-07-1Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s diseaseamyloidintracellularoligomersmall moleculetoxicityInhibitorinhibitorinhibit

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