2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. β-Sanshool

β-Sanshool 主要存在于花椒中，具有独特的辛辣感。β-Sanshool 是一种 TRPV1 激活剂，可激活 TRPV1 以升高细胞内钙浓度。β-Sanshool 有抗氧化作用，可增强自由基清除活性。β-Sanshool 可提高热变性温度，稳定蛋白质结构。β-Sanshool 可诱导麻木和苦味感官体验。

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β-Sanshool

β-Sanshool Chemical Structure

CAS No. : 10076-00-3

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β-Sanshool 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness[1][2].

IC50 & Target[2]

rTRPV1

 

体外研究
(In Vitro)

β-sanshool (质量比 1:15000 至 1:2500；11-33 min 100 °C incubation) 可提升鸭肉肌原纤维蛋白的自由基清除活性[1]。
β-sanshool (质量比 1:15000 至 1:2500；11-33 min 100 °C incubation) 可降低鸭肉肌原纤维蛋白的氧化损伤，可使羰基含量降低 57.96%，游离巯基含量升高 32.16%[1]。
β-sanshool (质量比 1:15000 至 1:2500；100 °C 孵育 11-33 min) 促进鸭肉肌原纤维蛋白三级结构的折叠，保持二级结构稳定性，降低表面疏水性，提高鸭肉肌原纤维蛋白的热稳定性[1]。
β-Sanshool 可微弱激活稳定表达于 HEK293VR11 细胞中的大鼠 TRPV1，其 EC50 为 54 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Sanshool 相关抗体:
分子量

247.38

Formula

C16H25NO
CAS 号
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Sanshool 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Sanshool10076-00-3TRP ChannelTransient receptor potential channelsratHEK293VR11 cellsduck meat myofibrillar proteincarbonyl contentsulfhydryl groupsfree radical scavenging activitysecondary structuremeat processing qualityTRPV1tertiary structureInhibitorinhibitorinhibit

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