2. Cell Cycle/DNA Damage
  3. CDK
  4. BMS-357075

BMS-357075 是一种泛 CDK 抑制剂，其 CDK1 IC50 为 18 nM、CDK2 IC50 为 3 nM、CDK4 IC50 为 26 nM。BMS-357075 可诱导人卵巢癌 A2780 细胞产生细胞毒性。BMS-357075 在小鼠体内对 P388 鼠白血病表现出抗癌活性。BMS-357075 可用于白血病的研究。

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BMS-357075

BMS-357075 Chemical Structure

CAS No. : 350509-99-8

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BMS-357075 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-357075 is a pan-CDK inhibitor with CDK1 IC50 18 nM, CDK2 IC50 3 nM, CDK4 IC50 26 nM. BMS-357075 induces cytotoxicity in human ovarian cancer A2780 cells. BMS-357075 exhibits anticancer activity in mice against P388 murine leukemia. BMS-357075 can be used for the research of leukemia[1].

IC50 & Target[1]

CDK1/cyclinB1

18 nM (IC50)

CDK2/cyclinE

3 nM (IC50)

CDK4/cyclin D

26 nM (IC50)

体外研究
(In Vitro)

BMS-357075 (compound 19) 可在无细胞酶实验中强效抑制 CDK1/cyclin B (IC50 = 18 nM)、CDK2/cyclin E (IC50 = 3 nM) 及 CDK4/cyclin D (IC50 = 26 nM)[1]。
BMS-357075 可强效抑制人卵巢癌细胞 A2780 的活力，其 IC50 为 3 nM[1]。
BMS-357075 在小鼠血清中的蛋白结合率为 90%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-357075 相关抗体:
体内研究
(In Vivo)

BMS-357075 (compound 19) (4 mg/kg；腹腔注射；每日 1 次；连续 7 天) 可使免疫功能正常小鼠的 P388 小鼠白血病生存时间延长 56% (%T/C = 156)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

461.64

Formula

C22H31N5O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-357075 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-357075350509-99-8BMS357075BMS 357075CDKCyclin dependent kinaseCDK2cyclin ECDK4cyclin Dimmunocompetent miceP388 murine leukemiahuman ovarian cancer A2780 cellsmouse serumcyclin BCDK1Inhibitorinhibitorinhibit

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产品名称：
BMS-357075
目录号：
HY-182734
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