2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. BRL-37344

BRL-37344 是一种 β-肾上腺素受体 (β-adrenoceptor) 激动剂，对 β3、β2 和 β1 的 EC50 值分别为 5.3、18 和 570 nM。BRL-37344 可诱导心房率呈浓度依赖性升高、豚鼠气管舒张以及棕色脂肪细胞脂解。

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BRL-37344

BRL-37344 Chemical Structure

CAS No. : 114333-71-0

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Other Forms of BRL-37344:

BRL-37344 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes[1].

IC50 & Target[1]

β3 adrenoceptor

5.3 nM (EC50)

β2 adrenoceptor

18 nM (EC50)

β1 adrenoceptor

570 nM (EC50)

体外研究
(In Vitro)

BRL-37344 (0.1 nM-10 μM) 可诱导心房率呈浓度依赖性升高，其 EC50 值为 0.57 μM；还可诱导豚鼠气管舒张，其 EC50 值为 18 nM[1]。
BRL-37344 (0.1 nM-1 μM) 可诱导棕色脂肪细胞呈浓度依赖性脂解，其 EC50 值为 5.3 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRL-37344 相关抗体:
分子量

363.84

Formula

C19H22ClNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRL-37344 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL-37344114333-71-0BRL37344BRL 37344Adrenergic ReceptorBeta Receptorobesityβ-adrenoceptorβ3β2β1diabetesmale Wistar ratsrat right atrial rateInhibitorinhibitorinhibit

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产品名称：
BRL-37344
目录号：
HY-101325B
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