2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. Buddlejasaponin I

Buddlejasaponin I (Verbascosaponin B) 是一种 COX 和 5-LOX 抑制剂。Buddlejasaponin I 可抑制 COX 代谢产物 PGE2、TXB2 以及 5-LOX 代谢产物 LTC4 的生成。Buddlejasaponin I 可减轻小鼠耳肿胀。Buddlejasaponin I 可用于炎症相关研究。

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Buddlejasaponin I

Buddlejasaponin I Chemical Structure

CAS No. : 139501-36-3

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Buddlejasaponin I 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Buddlejasaponin I (Verbascosaponin B) is an inhibitor of COX and 5-LOX. Buddlejasaponin I inhibits the production of COX metabolites PGE2, TXB2, and the 5-LOX metabolite LTC4[1]. Buddlejasaponin I reduces ear swelling in mice. Buddlejasaponin I is applicable to inflammation-related research[1].

IC50 & Target[1]

5-LOX

 

体外研究
(In Vitro)

Buddlejasaponin I 可强效抑制钙离子载体 A23187 (HY-N6687) 刺激的小鼠腹腔巨噬细胞释放 LTC4，其 IC50 为 2.4 μM，在 100 μM 浓度下抑制率可达 100%[1]。
Buddlejasaponin I 可轻度抑制钙离子载体 A23187 刺激的小鼠腹腔巨噬细胞释放 PGE2，其 IC50 为 93 μM，在 100 μM 浓度下抑制率达 40.4%[1]。
Buddlejasaponin I 可抑制钙离子载体 A23187 刺激的人血小板释放 TXB2，其 IC50 为 27 μM，在 100 μM 浓度下抑制率达 76.7%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Buddlejasaponin I 相关抗体:
体内研究
(In Vivo)

Buddlejasaponin I (1 mg/ear；局部给药；单次剂量) 可对 PMA (HY-18739) 诱导的小鼠耳水肿产生 94.41% 的抑制作用，但对相关血管通透性无显著降低作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (female, 8 weeks old)[1]
Dosage: 1 mg/ear
Administration: topical; single dose
Result: Achieved 94.41% inhibition of PMA-induced ear edema at 3 hours post-PMA.
Exerted only 2.99% inhibition of PMA-induced vascular permeability, which was not a significant effect.
分子量

1089.26

Formula

C54H88O22
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Buddlejasaponin I 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Buddlejasaponin I139501-36-3Verbascosaponin BCOXLipoxygenaseCyclooxygenaseLOX5-LOXPGE2mouse peritoneal macrophagesTXB2Verbascum songaricum5-lipoxygenasecyclooxygenaseLTC4human plateletsInhibitorinhibitorinhibit

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目录号：
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