2. Immunology/Inflammation
  3. Interleukin Related
  4. Calonysterone

Calonysterone 是一种口服有效的 IL-6 抑制剂。Calonysterone 可降低炎性细胞因子 IL-6 的水平。Calonysterone 可预防饮食诱导的肥胖。Calonysterone 可使异常的血浆脂联素和瘦素浓度恢复正常。Calonysterone 可提高总 DNA 甲基化百分比。Calonysterone 可增强抗氧化活性。Calonysterone 可用于肥胖相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Calonysterone

Calonysterone Chemical Structure

CAS No. : 51787-31-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Calonysterone 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Calonysterone is an orally effective IL-6 inhibitor. Calonysterone reduces the level of the proinflammatory cytokine IL-6. Calonysterone prevents diet-induced obesity. Calonysterone normalizes abnormal plasma adiponectin and leptin concentrations. Calonysterone increases the percentage of total DNA methylation. Calonysterone enhances antioxidant activity. Calonysterone is applicable to obesity-related research[1].

IC50 & Target[1]

IL-6

 

体内研究
(In Vivo)

Calonysterone (10 mg/kg；口服；每日一次；持续 12 周) 可完全预防雄性 Sprague-Dawley 大鼠由高脂高糖饮食诱导的肥胖，使脂肪因子水平恢复正常，增强肝脏抗氧化能力，降低炎性 IL-6 水平，并提升肝脏整体 DNA 甲基化水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 6 weeks old, obesity induced by 12-week high-fat, high-sugar diet)[1]
Dosage: 10 mg/kg
Administration: p.o.; daily; 12 weeks
Result: Fully prevented HFHSD-induced body weight gain.
Normalized plasma leptin and adiponectin levels altered by HFHSD.
Significantly increased liver total antioxidant capacity and catalase levels compared to the HFHSD group.
Did not change liver superoxide dismutase levels relative to the standard diet control.
Counteracted HFHSD-induced increases in liver IL-6 mRNA and protein expression, and decreased plasma IL-6 levels.
Significantly increased global DNA methylation in the liver compared to the standard diet control group.
分子量

476.60

Formula

C27H40O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Calonysterone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calonysterone51787-31-6Interleukin RelatedILadiponectinantioxidant activityinflammatory cytokineSprague-Dawley ratsinterleukin-6Asparagus dumosusobesityDNA methylationleptindiet-induced obese rodent modelsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Calonysterone
目录号：
HY-N19725
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z