2. Immunology/Inflammation
  3. CD38
  4. CD38-IN-6

CD38-IN-6 是一种具有口服活性的 CD38 抑制剂。CD38-IN-6 可通过提升 NAD+ 和 NMN 水平、降低 NAM 和 ADPR 水平来调控老年肥胖小鼠肝脏中的 NAD+ 代谢物水平。CD38-IN-6 减轻小鼠体内的炎症反应。CD38-IN-6 可用于肥胖、炎症相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

CD38-IN-6

CD38-IN-6 Chemical Structure

CAS No. : 2766686-04-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CD38-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CD38-IN-6 is an orally active CD38 inhibitor. CD38-IN-6 regulates NAD+ metabolite levels in the liver of aged obese mice by increasing NAD+ and NMN levels, and decreasing NAM and ADPR levels. CD38-IN-6 alleviates inflammatory responses in mice. CD38-IN-6 can be used for research related to obesity and inflammation[1].

体外研究
(In Vitro)

CD38-IN-6 (Compound 39) (8 different concentrations; 10 min) 可强效抑制原代人 M1 巨噬细胞中 CD38 介导的 NAD+ 水解酶活性，其 IC50 为 3.9 nM[1]。
CD38-IN-6 (50 nM; 24 h) 可显著调控表达 CD38 的 NH7-dCas9 Jurkat T 细胞中的细胞内钙流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CD38-IN-6 相关抗体:
体内研究
(In Vivo)

CD38-IN-6 (1-10 mg/kg；口服；单次给药/每日 2 次；持续 49 天) 可通过提升 NAD+ 和 NMN 水平、降低 NAM 和 ADPR 水平来调控肥胖小鼠肝脏中的 NAD+ 代谢物水平[1]。
CD38-IN-6 (10 mg/kg；口服；每日 2 次；连续 5 天) 可通过提升 NAD+ 和 NMN 水平、降低 NAM 和 ADPR 水平来调控老年肥胖小鼠肝脏中的 NAD+ 代谢物水平[1]。
CD38-IN-6 (10-30 mg/kg；口服) 可通过减少促炎细胞因子、调节脾脏和肝脏中的 NAD+ 代谢物水平、降低肝脏中 CD38 表达及炎症基因表达，减轻小鼠体内 LPS (HY-D1056) 诱导的炎症反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6/J (male, 7.5 months old, diet-induced obese)[1]
Dosage: 1 mg/kg; 10 mg/kg
Administration: p.o.; single dose/p.o.; twice daily; 49 days
Result: Increased liver NAD+ and NMN levels relative to vehicle control.
Decreased liver NAM and ADPR levels relative to vehicle control.
Animal Model: C57BL6/J (male, 19-22 months old, diet-induced obese)[1]
Dosage: 10 mg/kg
Administration: p.o.; twice daily; 5 days
Result: Increased liver NAD+ and NMN levels relative to vehicle control.
Decreased liver NAM and ADPR levels relative to vehicle control.
Animal Model: C57BL/6J (male, 12 weeks old, LPS-induced inflammation)[1]
Dosage: 10 mg/kg; 30 mg/kg
Administration: p.o.
Result: Caused statistically significant decreases in plasma IL-6, TNFα, and IP-10 at 8-hour post-LPS challenge.
Caused statistically significant decreases in plasma IP-10 at 4-hour post-LPS challenge; 10 mg/kg caused a 43% decrease in IL-6 and 22% decrease in TNFα; 30 mg/kg caused a 75% decrease in IL-6 and 58% decrease in TNFα.
Caused a 2.3-fold increase in spleen NAD+ levels and a 40% decrease in spleen ADPR levels at 8-hour post-LPS challenge; 10 mg/kg and 30 mg/kg caused statistically significant decreases in spleen MIP1α, MIP2, TNFα, RANTES, MCP1, IL-1β, IL-6, IP-10, and IFNγ levels at 8-hour post-LPS challenge.
Caused a 2-fold increase in liver NAD+ levels at 8-hour post-LPS challenge, and 30 mg/kg caused a 38% decrease in liver NAM levels at 8-hour post-LPS challenge; caused decreases in liver ADPR levels at 4-hour post-LPS challenge; caused statistically significant decreases in liver CD38 expression, as well as statistically significant decreases in liver MIP1α, MIP2, TNFα, RANTES, MCP1, IL-1β, IL-6, IP-10, and IFNγ levels at 8-hour post-LPS challenge.
分子量

408.33

Formula

C17H15F3N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CD38-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD38-IN-62766686-04-6CD38NH7-dCas9 Jurkat T cellsobese miceaged obese miceprimary human M1 macrophagespro-inflammatory cytokinesobesityLPS-induced inflammationlps-induced inflammationNAD+Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CD38-IN-6
目录号：
HY-186178
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z