2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-33 maleate

CDK7-IN-33 (formula Ⅰ) maleate 是一种嘧啶衍生物，同时也是 CDK7 激酶抑制剂。CDK7-IN-33 maleate 可用于癌症、炎症、心血管疾病、感染性疾病、免疫疾病及代谢疾病的研究。

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CDK7-IN-33 maleate

CDK7-IN-33 maleate Chemical Structure

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规格 是否有货
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Customer Review

Other Forms of CDK7-IN-33 maleate:

CDK7-IN-33 maleate 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK7-IN-33 (formula Ⅰ) maleate is a pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 maleate is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases[1].

体外研究
(In Vitro)

CDK7-IN-33 (formula Ⅰ) maleate crystal form Form I (0.15-333.33 nM; 3 天) 可强效抑制 23 种人类癌细胞系的增殖，这些细胞系包括卵巢癌、结直肠癌、乳腺癌、肺癌、胰腺癌、白血病及淋巴瘤细胞系，其剂量依赖性抗增殖活性可证明这一点[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-33 maleate 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Ovarian cancer A2780 cells, colorectal cancer WiDr cells, plus 21 additional human cancer cell lines including triple-negative breast cancer HCC70, ER+ HER2- breast cancer T47D, palbociclib-resistant breast cancer xMCF-7/palbo-R, non-small cell lung cancer A549, small cell lung cancer NCI-H446, ovarian cancer OVCAR-3, pancreatic cancer PANC-1, myeloid monocytic leukemia MV-4-11, and mantle lymphoma Mino cells
Concentration: 0.15-333.33 nM
Incubation Time: 3 days
Result: Inhibited proliferation of all 23 tested cancer cell lines, with measured anti-proliferative activity reported as IC50 values for each cell line.
体内研究
(In Vivo)

CDK7-IN-33 (10 mg/kg；灌胃) maleate 在大鼠体内展现出优异的体内动力学特性，灌胃给予 10 mg/kg 剂量后，其 AUC0-∞ 为 1732.07 h*ng/mL，Cmax 为 270.53 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

618.49

Formula

C25H24F6N6O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK7-IN-33 maleate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-33CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181565A
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