2. GPCR/G Protein
  3. Endothelin Receptor
  4. Cgs 27830

Cgs 27830 是一种内皮素受体 (endothelin receptor) 拮抗剂，对 ET-A 受体的选择性比 ET-B 受体高 20 倍。Cgs 27830 可阻断 ET-A 和 ET-B 受体的活性。Cgs 27830 不会改变绵羊胎儿肺循环的基础血管张力。Cgs 27830 可防止妊娠晚期胎羊体内大内皮素-1 诱导的肺血管收缩。

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Cgs 27830

Cgs 27830 Chemical Structure

CAS No. : 155485-56-6

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Cgs 27830 相关抗体

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ETA ETB

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs[1].

体内研究
(In Vivo)

CGS 27830 (100 mcg/min；肺内输注；10 min) 不会改变妊娠晚期胎羊的基础肺血管张力，但可完全阻断 big-ET-1 诱导的肺血管收缩[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Columbia-Rambouillet (mixed breed, late gestation 131 days)[1]
Dosage: 100 mcg/min
Administration: intrapulmonary infusion; 10 min
Result: Did not alter baseline left pulmonary artery flow, mean pulmonary artery pressure, mean aortic pressure, left atrial pressure, pulmonary vascular resistance, heart rate, or blood gas parameters.
Blocked the big-ET-1-induced increase in pulmonary vascular resistance.
Blocked the big-ET-1-induced rise in mean pulmonary artery pressure.
Prevented changes in left pulmonary artery flow.
分子量

646.60

Formula

C32H30N4O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cgs 27830 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cgs 27830155485-56-6Cgs27830Cgs-27830Endothelin Receptorovine fetal pulmonary circulationendothelin receptor antagonistET-B receptorslate gestation fetal lambsbig-endothelin-1ET-A receptorspulmonary vasoconstrictionInhibitorinhibitorinhibit

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