2. Immunology/Inflammation Apoptosis
  3. Interleukin Related IFNAR TNF Receptor Apoptosis
  4. Chamissonolide

Chamissonolide 是一种倍半萜内酯，具有细胞毒性、抗炎和抗锥虫活性。Chamissonolide 可降低 IL-2、IFN-γ、GM-CSF、iNOS、TNF-α mRNA 水平，上调 NF-ATc mRNA 水平。Chamissonolide 可减少天然存在的凋亡 (apoptosis) 细胞群体。Chamissonolide 可用于肿瘤、非洲锥虫病和恰加斯病的相关研究。

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Chamissonolide

Chamissonolide Chemical Structure

CAS No. : 78853-98-2

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Chamissonolide 相关抗体

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查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chamissonolide is a sesquiterpene lactone with cytotoxic, anti-inflammatory and trypanocidal activities. Chamissonolide reduces the mRNA levels of IL-2, IFN-γ, GM-CSF, iNOS and TNF-α, and upregulates the mRNA level of NF-ATc. Chamissonolide decreases the population of naturally occurring apoptotic cells. Chamissonolide can be used in research related to tumors, African trypanosomiasis and Chagas disease[1][2][3].

IC50 & Target[1]

IL-2

 

体外研究
(In Vitro)

Chamissonolide (Compound 3) (72 h) 对 KB 上皮肿瘤细胞的基线细胞毒性 IC50 为 2.3 μM[1]。
Chamissonolide (5-20 μM; 2.5-20 h) 下调 PMA (HY-18739) 刺激的人外周血单个核细胞 (PBMCs)、CD4+ Jurkat T 中特定促炎细胞因子的 mRNA (IL-2、IFN-γ、GM-CSF、iNOS、TNF-α)，上调 NF-ATc 的 mRNA[2]。
Chamissonolide (0.5-80 μM; 2.5-72 h) 作用 72 小时后对 CD4+ Jurkat T 细胞的 IC50 为 13 μM[2]。
Chamissonolide (10-20 μM; 20 h) 降低 CD4+ Jurkat T 细胞中自然发生的细胞凋亡[2]。
Chamissonolide (compound 4) (0.123-90 μg/mL; 72-96 h) 可抑制 Trypanosoma brucei rhodesiense STIB 900 的生长，其 IC50 为 9.275 μM；可抑制 Trypanosoma cruzi Tulahuen 株 C2C4，IC50 为 45.833 μM；同时对大鼠骨骼肌成肌细胞 L-6 表现出细胞毒性，IC50 为 15.191 μM[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chamissonolide 相关抗体:

Real Time qPCR[2]

Cell Line: PMA-stimulated CD4+ Jurkat human leukemia T cells
Concentration: 10 μM
Incubation Time: 2.5 h; 5 h; 20 h
Result: Down-regulated PMA-induced pro-inflammatory cytokine mRNA levels similarly to its effects in PBMCs at 10 μM.
Did not alter mRNA levels of house-keeping genes (GAP-DH, β-actin), cell homeostasis factors (cyclin D1, bcl-2), or I-κBα.
Significantly up-regulated NF-ATc mRNA levels after 20 hours of treatment at 10 μM.

Cell Viability Assay[2]

Cell Line: CD4+ Jurkat human leukemia T cells, PBMCs
Concentration: 0.5 μM; 1 μM; 2.5 μM; 5 μM; 10 μM; 20 μM; 40 μM; 80 μM
Incubation Time: 2.5 h; 20 h; 72 h
Result: Was not significantly cytotoxic against PBMCs at concentrations up to 40 μM at all tested time points.
Showed cytotoxicity in Jurkat T cells first observed between 20 and 72 hours at higher concentrations, with an IC50 of 13 μM after 72 hours.
Did not significantly reduce viability of either cell type at 10 μM over 72 hours, and showed cytoprotective effects in PBMCs after 72 hours as indicated by increased WST-1 cleavage.

Apoptosis Analysis[2]

Cell Line: CD4+ Jurkat human leukemia T cells
Concentration: 10 μM; 20 μM
Incubation Time: 20 h
Result: Reduced the number of apoptotic Jurkat T cells compared to untreated controls at 10 μM, with cell morphology identical to normal control populations.
Did not induce caspase-8 or caspase-3 activity at concentrations up to 20 μM.
分子量

324.37

Formula

C17H24O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chamissonolide 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chamissonolide78853-98-2Interleukin RelatedIFNARTNF ReceptorApoptosisILInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRhuman PBMCsCD4+ T cellsL-6 rat skeletal myoblastsTrypanosoma brucei rhodesienseNF-ATciNOSCD4+ Jurkat T cellsTrypanosoma cruziKB epithelial tumor cellsArnica speciesInhibitorinhibitorinhibit

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