1. Immunology/Inflammation Apoptosis
  2. Interleukin Related TNF Receptor
  3. CJ-14897

CJ-14897 是一种细胞因子产生抑制剂,其对 IL-1β 和 TNF-α 产生的 IC50 值分别为 0.059 μM 和 0.59 μM,对亮氨酸摄取的 IC50 为 180 μM。CJ-14897 可从担子菌小皮伞属菌株 CL21624 的发酵液中发现。

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CJ-14897

CJ-14897 Chemical Structure

CAS No. : 377755-95-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CJ-14897 is a cytokine production inhibitor, with IC50 values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC50 of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624[1][2].

IC50 & Target[1]

IL-1β

59 nM (IC50)

体外研究
(In Vitro)

CJ-14,897 可强效抑制 LPS (HY-D1056) 诱导的人全血中 IL-1β 和 TNF-α 的产生,其 IC50 值分别为 0.059 μM 和 0.59 μM;同时该化合物对总蛋白质合成的抑制作用较弱,IC50 为 180 μM[1]
CJ-14897 可抑制人全血中 LPS 诱导的 IL-1β 和 TNF-α 产生,其 IC50 值范围为 0.059 至 2.6 μM[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

253.25

Formula

C12H15NO5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CJ-14897
目录号:
HY-182630
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