2. Neuronal Signaling MAPK/ERK Pathway PI3K/Akt/mTOR Cytoskeleton Cell Cycle/DNA Damage
  3. Choline Kinase p38 MAPK PI3K Akt Arp2/3 Complex PERK
  4. CK37

CK37 是一种竞争性的胆碱激酶-α (choline kinase-α) 抑制剂。CK37 可抑制纯化的重组人胆碱激酶-α 的活性。CK37 可抑制 MAPK 和 PI3K/AKT 信号通路，并破坏 actin 细胞骨架的组织结构。CK37 可减弱 ERK 的激活磷酸化水平。CK37 对宫颈癌、黑色素瘤、Lewis 肺癌、肺腺癌、乳腺癌和白血病均具有抗癌活性。

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CK37

CK37 Chemical Structure

CAS No. : 1001478-90-5

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CK37 相关抗体

Top Publications Citing Use of Products

查看 Choline Kinase 亚型特异性产品:

查看所有亚型
CHKα

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CK37 is a competitive choline kinase-α inhibitor. CK37 inhibits purified recombinant human choline kinase-α activity. CK37 suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization. CK37 diminishs activating phosphorylations of ERK. CK37 exhibits anticancer activity against cervical cancer, melanoma, Lewis lung carcinoma, lung adenocarcinoma, breast cancer, and leukemia[1].

IC50 & Target[1]

CHKα1

 

CHKα2

 

分子量

366.48

Formula

C20H22N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CK37 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK371001478-90-5CK 37CK-37Choline Kinasep38 MAPKPI3KAktArp2/3 ComplexPERKCKChoKcholine phosphokinasePhosphoinositide 3-kinasePKBProtein kinase BActin-related protein 2/3 complex Protein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseInhibitorinhibitorinhibit

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