2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Cymserine

Cymserine 是一种可穿透血脑屏障的丁酰胆碱酯酶 (BuChE) 抑制剂，其 IC50 值为 56.43 nM，Ki 为 38 nM。Cymserine 可浓度依赖性地结合至 BuChE 的催化结构域，形成稳定的氨甲酰化酶复合物，并通过与 BuChE 更大的酰基结合口袋的结构相容性，表现出相对于乙酰胆碱酯酶的 BuChE 选择性。Cymserine 可用于阿尔茨海默病的研究。

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Cymserine

Cymserine Chemical Structure

CAS No. : 145209-39-8

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Cymserine 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease[1].

IC50 & Target[1]

BuChE

38 nM (Ki)

体外研究
(In Vitro)

Cymserine (0.02-0.12 μM; 0-60 min) 可强效抑制纯化的人丁酰胆碱酯酶 (BuChE)，其 IC50 范围为 63-100 nM (取决于底物浓度)，最低 IC50 为 56.43 nM，Ki 为 38 nM；同时该化合物呈现时间依赖性的结合活性丧失，活性丧失 50% 的临界时间为 7.54 min[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cymserine 相关抗体:
分子量

379.50

Formula

C23H29N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cymserine 相关分类

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  • 稀释计算器

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Keywords:

Cymserine145209-39-8Cholinesterase (ChE)blood-brain barrieracyl-binding pocketAlzheimer's diseasecarbamylated enzyme complexacetylcholinesterasehuman butyrylcholinesterasecatalytic domainBuChEInhibitorinhibitorinhibit

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