2. Cytoskeleton
  3. Arp2/3 Complex
  4. Deoxaphomin

Deoxaphomin 是一种细胞松弛素。Deoxaphomin 可抑制 Actin 丝延伸并降低聚合肌动蛋白丝的黏度。Deoxaphomin 可诱导成纤维细胞发生细胞变圆、肌动蛋白索收缩、含肌动蛋白的毛状结构以及胞质含肌动蛋白的杆状小体形成。Deoxaphomin 可抑制成纤维细胞的膜褶皱形成以及淋巴细胞的加帽作用。

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Deoxaphomin

Deoxaphomin Chemical Structure

CAS No. : 51053-39-5

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Deoxaphomin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes[1].

体外研究
(In Vitro)

Deoxaphomin (2-20 μM; 1 h) 在 20 μM 浓度下可诱导小鼠成纤维样 C3H 细胞在 1 小时内发生细胞圆化，但 2 μM 浓度下无此作用[1]。
Deoxaphomin (0.2-2 μM; 10 min) 在孵育 10 min 后，可在 2 μM 浓度下抑制小鼠成纤维 C3H 细胞的膜褶皱，但 0.2 μM 浓度下无此作用[1]。
Deoxaphomin 可诱导小鼠成纤维 C3H 细胞发生肌动蛋白丝收缩，并形成含肌动蛋白的毛状结构[1]。
Deoxaphomin (20 μM; 10 min) 经 20 μM 浓度预处理 10 min 后，可抑制小鼠脾淋巴细胞的加帽反应达 70%[1]。
Deoxaphomin (20 μM) 可使纯化的聚合兔骨骼肌肌动蛋白丝的比黏度降低 12%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxaphomin 相关抗体:
分子量

463.61

Formula

C29H37NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Deoxaphomin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxaphomin51053-39-5Arp2/3 ComplexActin-related protein 2/3 complexmouse fibroblastic C3H cellsrabbit skeletal muscle actin filamentsactin cable contractionactin filament elongationactinpolymerized actin filament viscosityactin-containing hairy structuresfibroblastic cellscytoplasmic actin-containing rodletsmouse splenic lymphocytesInhibitorinhibitorinhibit

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