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  4. Dianellin

Dianellin 是一种具有口服活性的抗疟剂，被发现存在于 Kniphofia foliosa 中。Dianellin 可与伯氏疟原虫 (Plasmodium falciparum) 的血浆酶 II 结合，并在小鼠体内表现出抗疟活性。Dianellin 可用于疟疾的相关研究。

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Dianellin

Dianellin Chemical Structure

CAS No. : 58829-72-4

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Dianellin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria[1].

体外研究
(In Vitro)

Dianellin 可与伯氏疟原虫 (Plasmodium falciparum) 天冬氨酸蛋白酶 II 弱结合，且不结合伯氏疟原虫 (Plasmodium falciparum) pfLDH[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dianellin 相关抗体:
体内研究
(In Vivo)

Dianellin (25-100 mg/kg；灌胃；每日给药；共 4 天) 在瑞士白化小鼠体内对伯氏疟原虫表现出剂量依赖性的体内抗疟活性，其 ED50 为 92.31 mg/kg，在最高测试剂量下疟原虫血症抑制率可达 53.77%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino (5-6 weeks old, 20-25 g, male or female, intraperitoneally inoculated with Plasmodium berghei ANKA strain-infected erythrocytes)[1]
Dosage: 25, 50, 100 mg/kg
Administration: p.o.; daily; 4 days
Result: Achieved 29.83% parasitaemia suppression and a mean survival time of 7.6 days at 25 mg/kg/day.
Achieved 44.04% parasitaemia suppression and a mean survival time of 8.2 days at 50 mg/kg/day.
Achieved 53.77% parasitaemia suppression and a mean survival time of 8.2 days at 100 mg/kg/day.
Demonstrated statistically significant suppression compared to negative control (p < 0.001).
Had a median effective dose (ED50) of 92.31 mg/kg.
分子量

524.51

Formula

C25H32O12
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dianellin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dianellin58829-72-4Parasitel-lactate dehydrogenase*Kniphofa foliosa*Swiss albino mice*Plasmodium falciparum*plasmepsin IImalariarhizomespfLDHnaphthalene glycoside*Plasmodium berghei*Inhibitorinhibitorinhibit

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