2. Immunology/Inflammation
  3. NO Synthase
  4. Dihydroxanthohumol

Dihydroxanthohumol 是一种被发现存在于 Humulus lupulus L. 中的查尔酮类化合物。Dihydroxanthohumol 是一种一氧化氮 (NO) 生成抑制剂。Dihydroxanthohumol 可轻度抑制 LPS (HY-D1056)/IFN-γ 诱导的 iNOS 蛋白表达及 NO 生成。Dihydroxanthohumol 在高浓度下具有细胞毒性。

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Dihydroxanthohumol

Dihydroxanthohumol Chemical Structure

CAS No. : 102448-00-0

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Dihydroxanthohumol 相关抗体

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihydroxanthohumol is a chalcone found in Humulus lupulus L. Dihydroxanthohumol is a nitric oxide (NO) production inhibitor. Dihydroxanthohumol slightly suppresses LPS (HY-D1056)/IFN-γ-induced iNOS protein expression and NO production. Dihydroxanthohumol exhibits cytotoxicity at high concentrations[1].

体外研究
(In Vitro)

Dihydroxanthohumol (Compound 5) (1-100 μg/mL; 16 h) 可抑制 LPS (HY-D1056)/IFN-γ 诱导的小鼠巨噬细胞 RAW 264.7 中 NO 的生成，并在 5 μg/mL 浓度下轻度抑制 iNOS 蛋白的表达[1]。
Dihydroxanthohumol (10-100 μg/mL; 16 h) 对 RAW 264.7 细胞具有细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydroxanthohumol 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10, 50, 100 μg/mL
Incubation Time: 16 h
Result: Showed cell viability <50% at 50, 100 μg/mL.
Showed cell viability <80% at 10 μg/mL.
Showed cell viability >95% at 50, 100 μg/mL.
分子量

356.41

Formula

C21H24O5
CAS 号
中文名称

二氢黄腐酚
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dihydroxanthohumol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydroxanthohumol102448-00-0二氢黄腐酚NO SynthaseNitric oxide synthasesNOSiNOS protein expressionNO productionnitric oxideRAW 264.7 cellsmouse macrophagesinducible nitric oxide synthaseInhibitorinhibitorinhibit

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