2. Apoptosis Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Apoptosis Glutathione S-transferase Topoisomerase
  4. Diospyrin

Diospyrin 是一种双萘醌类抗癌剂，具有促凋亡 (apoptosis) 活性、谷胱甘肽 S-转移酶 (Glutathione S-transferase) 抑制活性以及拓扑异构酶 (Topoisomerase) I 抑制活性。Diospyrin 存在于多种柿属 (Diospyros) 植物的心材中，可用于研究艾氏腹水癌、急性髓系白血病、慢性粒细胞白血病、乳腺腺癌、宫颈上皮癌、恶性皮肤黑色素瘤、喉表皮样癌、人骨肉瘤和人淋巴母细胞癌。

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Diospyrin

Diospyrin Chemical Structure

CAS No. : 28164-57-0

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Diospyrin 相关抗体

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Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma[1].

IC50 & Target

Topoisomerase I

 

体外研究
(In Vitro)

Diospyrin 对 HL-60 和 K-562 细胞表现出低细胞毒性，其 IC50 值大于 100 μM[1]。
Diospyrin 对 A375、Hep2 和 EAC 癌细胞具有选择性细胞毒性 (IC50=0.8 μM, 3.6 μM, 0.8 μM)，而对非恶性 PBMC 的毒性则低得多 (IC50=78.3 μM)[1]。
Diospyrin 可抑制多种人源重组 GSTs，IC50=0.3-0.6 μM，可作为针对 GST 介导的耐药性的化学调节剂[1]。
Diospyrin (160 μg/mL) 可完全抑制 Raji 细胞中 EBV 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diospyrin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: (I) HL-60 and K-562 cells
(II) A375, Hep2, and EAC cancer cells
Concentration: IC50 Test
Incubation Time: /
Result: Inhibited A375, Hep2, and EAC cancer cells with IC50 values of 0.8 μM, 3.6 μM, and 0.8 μM respectively, with low cytotoxicity towards HL-60 and K-562 cells, IC50s >100 μM.
体内研究
(In Vivo)

Diospyrin 可通过将血液学和血清参数恢复至接近正常水平，在荷艾氏腹水癌的瑞士 A 系小鼠中发挥抗癌活性，提高小鼠的生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

374.34

Formula

C22H14O6
CAS 号
中文名称

柿双醌
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diospyrin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diospyrin28164-57-0柿双醌ApoptosisGlutathione S-transferaseTopoisomeraseGlutathione transferasesGSTsmalignant skin melanomaDiospyros plantsehrlich ascites carcinomachronic myelogenic leukemiacervical epithelial carcinomabreast adenocarcinomaglutathione S-transferaseacute myeloblastic leukemiatopoisomerase Ipro-apoptotic activityInhibitorinhibitorinhibit

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