2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Drug-Linker Conjugates for ADC Eukaryotic Initiation Factor (eIF) EGFR
  4. DL149

DL149 是由 eIF4A 抑制剂 FD236 (HY-186186) 和 ADC Linker 偶联而形成的抗体-药物偶联物 (ADC) 的一部分，具有潜在抗肿瘤活性。DL149 可结合抗 HER2 抗体形成完整的 ADC 分子，从而精准结合肿瘤细胞表面的 HER2 受体，被细胞内化后释放 eIF4A 抑制剂载荷。DL149 不可逆阻断肿瘤细胞的 mRNA 翻译过程，进而抑制肿瘤细胞增殖并诱导其死亡。DL149 在 SK-OV-3 异种移植肿瘤模型中展现出体内抗肿瘤活性，可用于 HER2 阳性实体瘤的研究。

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DL149

DL149 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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DL149 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DL149 is a component of an antibody-drug conjugate (ADC) formed by conjugating the eIF4A inhibitor FD236 (HY-186186) with an ADC linker, and exhibits potential antitumor activity. DL149 can bind to an anti-HER2 antibody to form a complete ADC molecule, which precisely binds to the HER2 receptor on the surface of tumor cells. After internalization into cells, it releases the eIF4A inhibitor payload. DL149 irreversibly blocks the mRNA translation process in tumor cells, thereby inhibiting tumor cell proliferation and inducing their death. DL149 exhibits in vivo antitumor activity in the SK-OV-3 xenograft tumor model, and can be used for the research of HER2-positive solid tumors[1].

IC50 & Target

eIF4A

 

体内研究
(In Vivo)

Trastuzumab (HY-P9907)-DL149 ADCs (包括 DAR4 和 DAR8 两种形式) (5-10 mg/kg) 在多种 HER2 表达肿瘤异种移植模型中展现出强劲的体内抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

914.01

Formula

C48H59N5O13
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DL149 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL149DL 149DL-149Drug-Linker Conjugates for ADCEukaryotic Initiation Factor (eIF)EGFREpidermal growth factor receptorErbB-1HER1Val-Ala dipeptidehemi-aminaleIF4Aher2-expressing cancerHER2-expressing tumor xenograft modelsInhibitorinhibitorinhibit

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HY-183253
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