2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-207

EGFR-IN-207 (Compound 5h) 是一种表皮生长因子受体 (EGFR) 激酶抑制剂，IC50 为 0.21 μM。EGFR-IN-207 可诱导细胞周期阻滞于 Sub-G1 期、促进凋亡 (Apoptosis)。EGFR-IN-207 对肺癌具有抗癌活性。EGFR-IN-207 在非癌细胞系中的毒性极低。EGFR-IN-207 可用于肺癌相关研究。

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EGFR-IN-207

EGFR-IN-207 Chemical Structure

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EGFR-IN-207 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-207 (Compound 5h) is an epidermal growth factor receptor (EGFR) kinase inhibitor with an IC50 of 0.21 μM. EGFR-IN-207 induces cell cycle arrest at the Sub-G1 phase and promotes Apoptosis. EGFR-IN-207 exhibits anticancer activity against lung cancer. EGFR-IN-207 shows extremely low toxicity in non-cancerous cell lines. EGFR-IN-207 can be used in lung cancer-related research[1].

体外研究
(In Vitro)

EGFR-IN-207 可强效抑制野生型 EGFR 激酶活性，其 IC50 为 0.21 ± 0.06 μM，效力优于 Erlotinib (HY-50896)[1]。
EGFR-IN-207 (0.1-100 μM; 72 h) 在 10 μM 浓度下分别使得 HBEC30KT 和 HEK293 细胞的存活率为 82% 和 83%[1]。
EGFR-IN-207 (0.5-10 μM; 72 h) 可强效且呈浓度依赖性地抑制 H1975 和 A549 人肺癌细胞的增殖[1]。
EGFR-IN-207 (5 μM; 24 h) 可在人肺癌细胞 H1975 和 A549 中诱导强烈的 Sub-G1 期细胞周期阻滞与细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-207 相关抗体:

Cell Proliferation Assay[1]

Cell Line: H1975 EGFR L858R/T790M mutant cells, A549 EGFR wild-type cells
Concentration: 0.5-10 μM
Incubation Time: 72 h
Result: Reduced viable cell percentage to 86% at 1 μM, 34% at 5 μM, and 27% at 10 μM in H1975 cells, surpassing erlotinib's effect (37% viability at 10 μM).
Reduced viable cell percentage to 91% at 1 μM and 36% at 10 μM in A549 cells, with activity comparable to erlotinib.

Apoptosis Analysis[1]

Cell Line: H1975, A549 human lung cancer cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Increased the apoptotic cell population to 18.7 ± 1.9% (from 1.9 ± 0.4% in control) in H1975 cells, exceeding erlotinib's effect (13.7 ± 3.2%).
Increased the apoptotic cell population to 15.8 ± 2.1% (from 2.1 ± 0.2% in control) in A549 cells, with activity comparable to erlotinib.
分子量

427.26

Formula

C20H13Cl2FN6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-207 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-207EGFRApoptosisEpidermal growth factor receptorErbB-1HER1epidermal growth factor receptorH1975HBEC30KTHEK293EGFR kinase domainapoptosisATP-binding pocketA549Sub-G1 phase cell cycle arrestlung cancerInhibitorinhibitorinhibit

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EGFR-IN-207
目录号：
HY-182073
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