2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. EP9

EP9 是一种靶向 CD63 的 7 氨基酸多肽。EP9 可特异性结合 CD63 的胞外区域，包括其大胞外环 (EC2) 的凹槽或中央腔的胞外末端，从而触发被修饰的纳米乳/脂质体的细胞内吞作用。EP9 可通过小窝和/或网格蛋白包被小泡促进被修饰的纳米乳/脂质体被活化的心脏成纤维细胞和心外膜基质细胞摄取。EP9 可用于心肌梗死、心脏纤维化的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

EP9

EP9 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

EP9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EP9 is a 7-amino acid peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis[1].

体外研究
(In Vitro)

EP9 (5 µg; 30 min) 可与小鼠心脏成纤维细胞、EpiSC、人原代心脏成纤维细胞及正常人皮肤成纤维细胞特异性结合，其中对小鼠 EpiSC 和人原代心脏成纤维细胞的结合亲和力最高[1]。
EP9 (1 mM; 1 h) 可特异性结合四跨膜蛋白 CD63--一种存在于人正常真皮成纤维细胞表面的跨膜蛋白，这一点已通过 EP9 探针样本相较于对照 MUT 探针样本的显著富集得到证实[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EP9 相关抗体:
体内研究
(In Vivo)

EP9 (每 100 µL EP9-PFC-NE 含 25 µg；总剂量 150 µL；静脉注射；单次给药) 可介导结合型 PFC-NE 在梗死心肌组织中的选择性聚集，且该物质优先被心脏成纤维细胞和心外膜基质细胞摄取[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 8-12 weeks old, 20-25 g, myocardial infarction induced by 50 min left anterior descending coronary artery ligation followed by reperfusion)[1]
Dosage: 25 µg EP9 per 100 µL PFC-NE; 150 µL EP9-PFC-NE
Administration: i.v.; single dose
Result: Localized a strong 19F signal specifically to the infarcted anterior wall of the left ventricle on in vivo MRI, with a signal-to-noise ratio significantly higher than that of the mutated peptide control.
Declined plasma 19F signal with a half-life of ~20 hours.
Showed a transmural 19F signal in the infarcted area that increased between 12 hours and 24 hours post-injection via ex vivo MRI.
Revealed EP9-PFC-NE uptake primarily by cardiac fibroblasts and epicardial stromal cells, with no detectable uptake in macrophages, cardiomyocytes, or endothelial cells via transmission electron microscopy.
Demonstrated intracellular particles had an average size of 118 nm, matching the pre-injection particle size of 124 nm.
分子量

1297.64

Formula

C56H100N18O13S2
Sequence

Ac-Lys-Leu-Met-Leu-Pro-Arg-Pro-Gly-Gly-Gly-Lys-Cys-NH2
Sequence Shortening

Ac-KLMLPRPGGGKC-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EP9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP9EP 9EP-9Transmembrane Glycoproteinmyocardial infarctionnormal human dermal fibroblastsmouse cardiac fibroblastshuman primary cardiac fibroblastscaveolaeepicardial stromal cellsactivated cardiac fibroblastsCD63cardiac fibrosisclathrin-coated pitsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
EP9
目录号：
HY-P11797
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z