2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. Esculeogenin A

Esculeogenin A 是番茄皂苷 Esculeoside A (HY-N18067) 的皂苷元。Esculeogenin A 是一种选择性 ACAT-1 和 ACAT-2 抑制剂。Esculeogenin A 可抑制 ACAT-1 的活性与表达，以及 ACAT-2 的活性，并抑制巨噬细胞中胆固醇酯的蓄积。Esculeogenin A 可用于动脉粥样硬化的研究。

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Esculeogenin A

Esculeogenin A Chemical Structure

CAS No. : 854381-37-6

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Esculeogenin A 相关抗体

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ACAT1 ACAT2 MGAT2 ACAT DGAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is a selective ACAT-1 and ACAT-2 inhibitor. Esculeogenin A inhibits the activity and expression of ACAT-1, as well as the activity of ACAT-2, and suppresses cholesterol ester accumulation in macrophages. Esculeogenin A can be used for the research of atherosclerosis[1].

IC50 & Target[1]

ACAT-1

 

ACAT-2

 

体外研究
(In Vitro)

Esculeogenin A (3) (10-100 μM; 24 h) 可以剂量依赖的方式强效抑制人单核细胞来源巨噬细胞 (HMDMs) 中胆固醇酯的蓄积，且不影响乙酰化低密度脂蛋白的摄取或降解，其中 50 μM 可使蓄积量降低 40%[1]。
Esculeogenin A (10-100 μM; 24 h) 可剂量依赖性地抑制 hACAT-1 CHO 细胞和 hACAT-2 CHO 细胞中的胆固醇酯积累[1]。
Esculeogenin A (10-100 μM) 可剂量依赖性地抑制 HMDMs、hACAT-1 CHO 细胞及 hACAT-2 CHO 细胞中的 ACAT 活性[1]。
Esculeogenin A (10-50 μM; 24 h) 可剂量依赖性地降低 HMDMs 中 ACAT-1 蛋白的表达，且不会改变 SR-A 或 SR-BI 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Esculeogenin A 相关抗体:

Western Blot Analysis[1]

Cell Line: human monocyte-derived macrophages (HMDMs)
Concentration: 10, 30, 50 μM
Incubation Time: 24 h
Result: Reduced ACAT-1 protein expression in HMDMs in a dose-dependent manner.
Left SR-A and SR-BI protein expression unchanged relative to controls.
体内研究
(In Vivo)

Esculeogenin A (3) (100 mg/kg/天；口服；每日；连续 90 天) 可由经口服给予的 Esculeoside A (HY-N18067) 在体内生成，且可在载脂蛋白 E 缺陷小鼠的主动脉中被检测到[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

447.65

Formula

C27H45NO4
CAS 号
中文名称

番茄皂苷元
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Esculeogenin A 相关分类

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Keywords:

Esculeogenin A854381-37-6番茄皂苷元AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasehuman monocyte-derived macrophageshepatocyteshACAT-1 CHO cellsatherosclerosisintestinal mucosal cellsACAT-2hACAT-2 CHO cellsmacrophagesapoE-deficient miceACAT-1Inhibitorinhibitorinhibit

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