2. Neuronal Signaling
  3. Tau Protein
  4. Etalanetug (Mouse IgG2a)

Etalanetug (Mouse IgG2a)  (Synonyms: 7G6 Antibody; 7G6-IgG2a)

目录号: HY-P990995A
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技术支持

Etalanetug (Mouse IgG2a) (7G6 Antibody) 是靶向 tau 蛋白微管结合区 HVPGG 基序的小鼠单克隆抗体。Etalanetug (Mouse IgG2a) 可降低多个脑区中不溶性 tau 蛋白的水平，并减少病理性 tau 蛋白的播种与扩散。Etalanetug (Mouse IgG2a) 可用于阿尔茨海默病的相关研究。

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Etalanetug (Mouse IgG2a)

Etalanetug (Mouse IgG2a) Chemical Structure

CAS No. : 2690265-18-8

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Etalanetug (Mouse IgG2a) 的其他形式现货产品:

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Etalanetug (Mouse IgG2a) 相关抗体

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  • 生物活性

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生物活性

Etalanetug (Mouse IgG2a) (7G6 Antibody) is a mouse monoclonal antibody targeting the HVPGG motif in the microtubule-binding domain of tau protein. Etalanetug (Mouse IgG2a) reduces the levels of insoluble tau protein in multiple brain regions and inhibits the seeding and spread of pathological tau protein. Etalanetug (Mouse IgG2a) is applicable to research related to Alzheimer's disease[1][2].

体外研究
(In Vitro)

Etalanetug (Mouse IgG2a) 以高亲和力结合重组野生型人源 2N4R tau 蛋白，其 Kd 值为 64 pM[1]。
Etalanetug (Mouse IgG2a) 可高亲和力结合重组人 P301S 突变型 2N4R tau 蛋白，其 Kd 值为 448 pM，低于其对重组野生型人 2N4R tau 蛋白的亲和力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Etalanetug (Mouse IgG2a) 相关抗体:
体内研究
(In Vivo)

Etalanetug (Mouse IgG2a) (3-40 mg/kg; 外周给药) 在 hTau 转基因小鼠阿尔茨海默病模型中显著降低多个脑区不溶性 tau 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hTau mice (6 months old) with AD brain‑derived seed‑injection into the left hippocampus[2]
Dosage: 3, 10, 40 mg/kg
Administration: Peripheral administration
Result: Rduced insoluble tau in the hippocampus and cortex of seeded hTau mice, and antibody target engagement in CSF increased in a dose‑dependent manner.
Reduced pathological tau seeding and spreading in this model.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Etalanetug (Mouse IgG2a) 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etalanetug (Mouse IgG2a)2690265-18-87G6 Antibody 7G6-IgG2aTau Proteincerebrospinal fluidpathological tau inclusionsHVPGG motifinsoluble tautau protein microtubule binding regionalzheimer’s diseaserecombinant human P301S mutant 2N4R tau protein4R-tau isoformstau proteinrecombinant wild-type human 2N4R tau proteinInhibitorinhibitorinhibit

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