2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. γ-Linolenic acid NHS ester

γ-Linolenic acid NHS ester 是 γ-Linolenic acid (GLA) (HY-N7140) 代谢的脂质化合物，可作为合成中间体或探针标记试剂、来制备 GLA 偶联物。在实际应用中，γ-Linolenic acid NHS ester 可与紫杉烷和多聚糖偶联为双型偶联体，用于药物递送的用途。

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γ-Linolenic acid NHS ester

γ-Linolenic acid NHS ester Chemical Structure

CAS No. : 216447-57-3

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γ-Linolenic acid NHS ester 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

γ-Linolenic acid NHS ester is a lipid metabolite of γ-Linolenic acid (GLA) (HY-N7140), which can serve as a synthetic intermediate or probe labeling reagent for the preparation of GLA conjugates. In practical applications, γ-Linolenic acid NHS ester can be conjugated with taxanes and polysaccharides to form dual-type conjugates for drug delivery purposes[1].

体外研究
(In Vitro)

紫杉烷类化合物是以紫杉烷二萜为骨架的天然及半合成衍生物，凭借抑制细胞有丝分裂的机制表现出显著抗癌活性，广泛用于乳腺癌、卵巢癌等多种实体瘤研究。但紫杉烷的水溶性极差，临床制剂需依赖 Cremophor EL、Tween-80 等含 PEG 片段的助溶剂，而这些助溶剂易诱发超敏反应、肾毒性、神经毒性及中性粒细胞减少症等，严重时可致死亡[1]。
γ-Linolenic acid NHS ester 作为酯类化合物，是构成细胞的重要成分，容易在肿瘤组织中聚集，可改善药物的体内吸收和分布情况、提高安全性和降低毒副作用。利用 γ-Linolenic acid NHS ester 偶联紫杉烷，有潜力解决紫杉烷的溶解度、生物利用度、毒副作用和肿瘤靶向性等问题[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Linolenic acid NHS ester 相关抗体:
分子量

375.50

Formula

C22H33NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

γ-Linolenic acid NHS ester 相关分类

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Keywords:

γ-Linolenic acid NHS ester216447-57-3Drug Metabolitelipid compound unitγ-linolenic acidInhibitorinhibitorinhibit

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