Gck - glucokinase Gene

中文名称：葡萄糖激酶

种属: Mus musculus

同用名: Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006

关于 Gck

功能概要

该基因编码的蛋白可启动葡萄糖激酶活性。参与钙离子输入；细胞葡萄糖稳态；胰岛素分泌的正调节作用。作用于几个过程的上游或内部，包括碳水化合物磷酸化；葡萄糖稳态；和胰岛素分泌的调节。位于胞质溶胶中；线粒体；和核。以多种结构表达，包括消化系统；脑;肌肉骨骼系统;生殖系统;和感觉器官。用于研究家族性高胰岛素血症性低血糖症 3；高胰岛素低血糖症;青年 2 型成人发病糖尿病；和 2 型糖尿病。该基因的人类直系同源物与动脉疾病有关（多个）；家族性高胰岛素血症性低血糖 3；和糖代谢疾病（多种）。与人 GCK（葡萄糖激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Glucokinase activity. Involved in calcium ion import; cellular glucose homeostasis; and positive regulation of Insulin secretion. Acts upstream of or within several processes, including carbohydrate phosphorylation; glucose homeostasis; and regulation of Insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; reproductive system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]