2. Gene
  3. Cdk9 - cyclin-dependent kinase 9 (CDC2-related kinase) Gene

Cdk9 - cyclin-dependent kinase 9 (CDC2-related kinase) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 9 (CDC2 相关激酶)

种属: Mus musculus

同用名: PITALRE

基因 ID: 107951 | 基因类型: protein coding

关于 Cdk9

Chromosome 2: 32,595,796-32,603,088 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 208 orthologues, 25 paralogues and is associated with 15 phenotypes. Ubiquitous expression in ovary adult (RPKM 28.4), thymus adult (RPKM 26.4) and 28 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 RNA 聚合酶 II CTD 七肽重复激酶活性；染色质结合活性；和核酸结合活性。参与组蛋白 H2B 泛素化的正调控和组蛋白磷酸化的正调控。位于核内。细胞周期蛋白/CDK 阳性转录延伸因子复合物的一部分。以多种结构表达，包括消化系统；早期胚胎；泌尿生殖系统；淋巴系统；和神经系统。与人 CDK9（细胞周期蛋白依赖性激酶 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including RNA polymerase II CTD heptapeptide repeat kinase activity; chromatin binding activity; and nucleic acid binding activity. Involved in positive regulation of histone H2B ubiquitination and positive regulation of histone phosphorylation. Located in nucleus. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Cdk9 基因产物(1)

mRNA Protein Name
NM_130860.3 NP_570930.1 cyclin-dependent kinase 9
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: 通过突变表型推断
22509028 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21245044 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16245309 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12037670 MGI
enables protein kinase binding IDA
IDA: 通过直接分析推断
22547058 MGI
enables snRNA binding IDA
IDA: 通过直接分析推断
16109376 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
20570862 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of mRNA 3'-end processing IMP
IMP: 通过突变表型推断
19575011 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: 通过直接分析推断
23752591 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16109376 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cdk9 蛋白结构

STKc_CDK9

STKc_CDK9: cd07865 (5 - 314)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 9

cell division protein kinase 9

Cdk9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cdk9 Q99J95 Max Mus musculus P28574
Anti Bait CoIP
20434984
种属内
Cdk9 Q99J95 Srsf2 Mus musculus Q62093
Anti Bait CoIP
23663783
种属内
Cdk9 Q99J95 Brdt Mus musculus Q91Y44
Pull Down
20593818
种属内
Cdk9 Q99J95 Brdt Mus musculus Q91Y44
Anti Bait CoIP
22922464
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.97% 是
HY-10492 Dinaciclib Inhibitor 99.80% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
Clinical Phase
生物活性分子 (28)
目录号 产品名 作用方式
纯度 Phase
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-112088 AZD4573 Inhibitor 99.98% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.21% Phase 2
HY-101212 Fadraciclib Inhibitor 99.78% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Phase 2
HY-137478 KB-0742 Inhibitor 99.38% Phase 2
HY-16559 Riviciclib hydrochloride 99.08% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-103712 Samuraciclib Inhibitor 99.55% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-138293 SY-5609 Inhibitor 99.93% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1
HY-103019B (-)-Enitociclib Inhibitor 99.85% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 99.75% Phase 1
Pre-clinical Phase
生物活性分子 (137)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103618 THZ531 Inhibitor 99.86% 否
HY-12214A NVP-2 Inhibitor 99.05% 否
HY-103248 Toyocamycin Inhibitor 99.27% 否
HY-101257 YKL-5-124 Inhibitor 99.53% 否
HY-103019 Enitociclib Inhibitor 99.89% 否
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% 否
HY-123954 BTX-A51 Inhibitor 98.58% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-130665 TL12-186 Inhibitor 99.63% 否
HY-11009 CGP60474 Inhibitor 98.90% 否
HY-130709 PROTAC CDK2/9 Degrader-1 Inhibitor 99.85% 否
HY-15878 LDC000067 Inhibitor 99.00% 否
HY-13914 Roniciclib Inhibitor 98.09% 否
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% 否
HY-143584 AZ5576 Inhibitor 99.86% 否
HY-12445 Asnuciclib Inhibitor 99.76% 否
HY-144117 GFB-12811 Inhibitor 98.04% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-103019A (±)-Enitociclib Inhibitor 99.23% 否
HY-X0150 JSH-150 Inhibitor 98.36% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.93% 否
HY-173523 KI-CDK9d-32 Degrader 99.03% 否
HY-12293 LY2857785 Inhibitor 99.92% 否
HY-112626 CDK12-IN-2 Inhibitor 99.36% 否
HY-103628 PROTAC CDK9 Degrader-1 Inhibitor 99.55% 否
HY-13461 PHA-767491 Inhibitor 99.97% 否
HY-13231 CDK9-IN-1 Inhibitor 98.52% 否
HY-124639 CDK9 inhibitor HH1 Inhibitor 99.69% 否
HY-101257B YKL-5-124 TFA Inhibitor 99.74% 否
HY-117203A CDK12-IN-E9 Inhibitor 99.71% 否
HY-16462 CDK9-IN-2 Inhibitor 98.72% 否
HY-13033 CDK-IN-2 Inhibitor 99.27% 否
HY-112403 (S)-Roscovitine Inhibitor 99.15% 否
HY-139980 CDK9-IN-13 Inhibitor 99.94% 否
HY-162706 BSJ-5-63 Degrader 99.97% 否
HY-12871 Atuveciclib Racemate Inhibitor 98.48% 否
HY-162037 CDDD11-8 Inhibitor 99.62% 否
HY-153260 TP-1287 Inhibitor 95.93% 否
HY-139329 CDK12-IN-6 Inhibitor 98.09% 否
HY-169244 CDK-TCIP1 Inhibitor 98.86% 否
HY-151069 TMX-2039 Inhibitor 99.42% 否
HY-139328 CDK12-IN-5 Inhibitor 98.03% 否
HY-14372 BS-194 Inhibitor 99.13% 否
HY-18944 FIT-039 Inhibitor 99.56% 否
HY-123955 Casein Kinase inhibitor A86 Inhibitor 99.26% 否
HY-102039 CDK9-IN-8 Inhibitor 99.16% 否
HY-126251 CDK9-IN-7 Inhibitor 98.05% 否
HY-168518 PROTAC CDK9 degrader-9 Degrader 99.25% 否
HY-115714 CDK9-IN-12 Inhibitor 99.65% 否
HY-130852 CDK9-IN-11 Inhibitor 97.02% 否
HY-100950 ABC1183 Inhibitor 99.62% 否
HY-112811 PROTAC CDK9 degrader-2 Inhibitor 99.22% 否
HY-178861 dCDK9-202 Degrader 99.25% 否
HY-103646 CK7 Inhibitor 99.72% 否
HY-119715 AG-012986 Inhibitor 99.78% 否
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% 否
HY-100429 CAN508 Inhibitor 99.59% 否
HY-176142 YX0798 Inhibitor 98.90% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-176165 CDK9/EZH2-IN-1 Inhibitor 97.03% 否
HY-130850 CDK9-IN-10 Inhibitor 98.09% 否
HY-155787 SHR5428 Inhibitor / 否
HY-143585 CDK9-IN-14 Inhibitor 99.91% 否
HY-153556 GW297361 Inhibitor 98.13% 否
HY-111388 Romaciclib Inhibitor 99.49% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-12843 Bohemine Inhibitor 98.93% 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-110368 BS-181 dihydrochloride Inhibitor / 否
HY-151436 ZLMT-12 Inhibitor / 否
HY-130001 CDK9-IN-9 Inhibitor / 否
HY-131063 CDK6/9-IN-1 Inhibitor / 否
HY-130981 FN-1501-propionic acid / 否
HY-164619 CDK9-IN-34 Inhibitor / 否
HY-153426 CDK9-IN-23 Inhibitor / 否
HY-173481 CDK9-IN-37 Inhibitor / 否
HY-176736 CDK9-IN-40 Inhibitor / 否
HY-175013 CDK6/9-IN-2 Inhibitor / 否
HY-179633 ZLMT-72 Inhibitor / 否
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / 否
HY-180912 HS-36 Inhibitor / 否
HY-121081A BAY-1112054 hydrochloride Inhibitor / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-156083 CDK9-IN-28 Inhibitor / 否
HY-139327 CDK12-IN-4 Inhibitor / 否
HY-173065 CDK9-IN-36 Inhibitor / 否
HY-178499 CDK9-IN-44 Inhibitor / 否
HY-176451 CDK9 degrader-1 Degrader / 否
HY-157980 CDK9-IN-32 Inhibitor / 否
HY-173348 BLINK15 Inhibitor / 否
HY-151898 CDK4/6-IN-14 Inhibitor / 否
HY-149870 PROTAC CDK9 degrader-8 Inhibitor / 否
HY-178733 A-1592668 Inhibitor / 否
HY-147794 CDK9-IN-41 Inhibitor 98.84% 否
HY-150641 CDK-IN-9 Inhibitor / 否
HY-172891 CDK9/HDAC1/HDAC3-IN-1 Inhibitor / 否
HY-123034 CDKI-83 Inhibitor / 否
HY-150562 CDK9-IN-19 Inhibitor / 否
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / 否
HY-177780 Cyclin K degrader 2 Degrader / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-181231 PROTAC CDK9 degrader-12 Degrader / 否
HY-179023 CDK9-IN-45 Inhibitor / 否
HY-161379 CLZX-205 Inhibitor / 否
HY-137478B KB-0742 hydrochloride Inhibitor / 否
HY-149962 PROTAC CDK9 degrader-5 Inhibitor / 否
HY-136841 SLM6 Inhibitor / 否
HY-150573 CDK2-IN-12 Inhibitor / 否
HY-151984 CDK9-IN-22 Inhibitor / 否
HY-170942 CDK9/PARP-IN-1 Inhibitor / 否
HY-156795 PROTAC CDK9/CycT1 Degrader-2 Inhibitor / 否
HY-155153 CDK9-IN-24 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-149963 PROTAC CDK9 degrader-6 Inhibitor / 否
HY-153718 KI-ARv-03 Inhibitor / 否
HY-164906 TMX-2138 Degrader / 否
HY-178039 CDK9-IN-42 Inhibitor / 否
HY-162619 CDK9-IN-33 Inhibitor / 否
HY-161595 CDK5-IN-4 Inhibitor / 否
HY-180817 CDK2-IN-55 Inhibitor / 否
HY-178112 CDK2-IN-47 Inhibitor / 否
HY-168896 CDK9 autophagic degrader 1 Degrader / 否
HY-180124 CDK8-IN-20 Inhibitor / 否
HY-161768 VCC972839:01 Inhibitor / 否
HY-170815 CDK4/9-IN-1 Inhibitor / 否
HY-179375 LCI133 Inhibitor / 否
HY-147771 ZLWT-37 Inhibitor / 否
HY-145408 CDK7/9-IN-1 Inhibitor / 否
HY-173347 BLINK11 Inhibitor / 否
HY-168845 CDK2/9-IN-1 Inhibitor / 否
HY-149495 CP-07 Degrader / 否
HY-123826 CCT68127 Inhibitor / 否
HY-119120 JTK-101 Inhibitor / 否
HY-112450 Olomoucine II Inhibitor / 否
HY-111356 IIIM-290 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk9 NCBI NCBI:1025
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