2. Gene
  3. Grk2 - G protein-coupled receptor kinase 2 Gene

Grk2 - G protein-coupled receptor kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Adrbk1; Bark-1; Adrbk-1; beta ARK; betaARK1

基因 ID: 110355 | 基因类型: protein coding

关于 Grk2

功能概要

Enables G protein-coupled receptor kinase activity. Involved in negative regulation of relaxation of smooth muscle. Acts upstream of or within several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart contraction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Grk2 基因产物(2)

mRNA Protein Name
NM_001290818.1 NP_001277747.1 beta-adrenergic receptor kinase 1 isoform 1
NM_130863.2 NP_570933.1 beta-adrenergic receptor kinase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor kinase activity IDA
IDA: 通过直接分析推断
1869533 MGI
enables G protein-coupled receptor kinase activity IMP
IMP: 通过突变表型推断
8917529 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15218143 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
15218143 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
17544362 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
14712229 MGI
acts upstream of or within desensitization of G protein-coupled receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
7761854 MGI
acts upstream of or within desensitization of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
10338466 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
8917529 MGI
involved in negative regulation of relaxation of smooth muscle IMP
IMP: 通过突变表型推断
30284927 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
17544362 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
17544362 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
15218143 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: 通过遗传相互作用推断
7761854 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
15218143 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

beta-adrenergic receptor kinase 1

adrenergic receptor kinase, beta 1

beta-AR kinase-1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0492 Paroxetine hydrochloride Inhibitor 99.98% 否
HY-B0492A Paroxetine hydrochloride hemihydrate Inhibitor 99.96% 否
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103045 CMPD101 Inhibitor 98.96% 否
HY-109562A CCG258208 hydrochloride 98.05% 否
HY-18991 CCG215022 Inhibitor 99.79% 否
HY-156863 GRK2 Inhibitor 2 Inhibitor 99.92% 否
HY-121983 CAY10594 Modulator 98.64% 否
HY-W013411A Locostatin Inhibitor 99.88% 否
HY-18990 GSK180736A Inhibitor 98.81% 否
HY-47573 CCG273441 Inhibitor 98.78% 否
HY-123538 GRK2 Inhibitor 1 Inhibitor 98.06% 否
HY-139690 CCG258747 Inhibitor 98.96% 否
HY-P1396A GRK2i TFA Inhibitor 99.89% 否
HY-129118 Takeda103A Inhibitor 98.69% 否
HY-177948 GRK2 degrader-1 Degrader 98.83% 否
HY-RS05813 GRK2 Human Pre-designed siRNA Set A Inhibitor / 否
HY-109562 CCG258208 Inhibitor / 否
HY-103045A CMPD101 hydrochloride Inhibitor / 否
HY-150022 GRK5-IN-4 Inhibitor / 否
HY-150039 CCG-271423 Inhibitor / 否
HY-119232 GSK466317A Inhibitor / 否
HY-120168 CCG 258001 Inhibitor / 否
HY-120718 CCG 224061 Inhibitor / 否
HY-P1396 GRK2i Inhibitor / 否
HY-123254 CCG-224406 Inhibitor / 否
HY-B0492S1 Paroxetine-d4 hydrochloride Inhibitor 99.16% 否
HY-168971 Paeoniflorin-6′-O-benzene sulfonate Inhibitor / 否
HY-118046 GSK2163632A Inhibitor / 否
HY-179707 GRL-03022 Inhibitor / 否
HY-155099 FGH31 / 否
HY-180583 GRK5-IN-5 Inhibitor / 否
HY-RS23286 Grk2 Rat Pre-designed siRNA Set A Inhibitor / 否
HY-RS16845 Grk2 Mouse Pre-designed siRNA Set A Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grk2 NCBI NCBI:156
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