2. Gene
  3. Gclc - glutamate-cysteine ligase, catalytic subunit Gene

Gclc - glutamate-cysteine ligase, catalytic subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Glclc; GLCL-H; Ggcs-hs; D9Wsu168e

基因 ID: 14629 | 基因类型: protein coding

关于 Gclc

功能概要

Enables glutamate-cysteine Ligase activity. Acts upstream of or within several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of cellular protein metabolic process. Located in cytosol. Part of glutamate-cysteine Ligase complex. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine Ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine Ligase catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclc 基因产物(1)

mRNA Protein Name
NM_010295.2 NP_034425.1 glutamate--cysteine ligase catalytic subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamate-cysteine ligase activity IDA
IDA: 通过直接分析推断
10966520 MGI
enables glutamate-cysteine ligase activity IMP
IMP: 通过突变表型推断
11118286 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12384496 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within L-ascorbic acid metabolic process IMP
IMP: 通过突变表型推断
11118286 MGI
acts upstream of or within glutathione biosynthetic process IDA
IDA: 通过直接分析推断
16081425 MGI
acts upstream of or within glutathione biosynthetic process IMP
IMP: 通过突变表型推断
10805773 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: 通过突变表型推断
11118286 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
17189825 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
17189825 MGI
acts upstream of or within regulation of mitochondrial depolarization IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within response to arsenic-containing substance IMP
IMP: 通过突变表型推断
17189825 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
17189825 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
12384496 MGI
part of glutamate-cysteine ligase complex IDA
IDA: 通过直接分析推断
12384496 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate--cysteine ligase catalytic subunit

GCS heavy chain

gamma GCS-HS

gamma-ECS

gamma-glutamylcysteine synthetase heavy subunit

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W015600 2-Acetamidophenol 99.61% 否
HY-171705 KMS99220 99.48% 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-RS05333 GCLC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W015600S 2-Acetamidophenol-d3 99.48% 否
HY-N17732 7-Hydroxy-5,3'4'-trimethoxyflavanone / 否
HY-N17855 Guavinoside B Inhibitor / 否
HY-RS17688 Gclc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24150 Gclc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gclc NCBI NCBI:2729
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