2. Gene
  3. Gclm - glutamate-cysteine ligase, modifier subunit Gene

Gclm - glutamate-cysteine ligase, modifier subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gcmc; Glclr

基因 ID: 14630 | 基因类型: protein coding

关于 Gclm

功能概要

Enables glutamate-cysteine Ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine Ligase activity. Part of glutamate-cysteine Ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine Ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclm 基因产物(1)

mRNA Protein Name
NM_008129.4 NP_032155.1 glutamate--cysteine ligase regulatory subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamate-cysteine ligase catalytic subunit binding IDA
IDA: 通过直接分析推断
12384496 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12384496 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic mitochondrial changes IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within cysteine metabolic process IMP
IMP: 通过突变表型推断
12384496 MGI
acts upstream of or within glutathione biosynthetic process IDA
IDA: 通过直接分析推断
16081425 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: 通过突变表型推断
12384496 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within positive regulation of glutamate-cysteine ligase activity IDA
IDA: 通过直接分析推断
12384496 MGI
acts upstream of or within regulation of mitochondrial depolarization IGI
IGI: 通过遗传相互作用推断
15288121 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
12384496 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of glutamate-cysteine ligase complex IDA
IDA: 通过直接分析推断
12384496 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate--cysteine ligase regulatory subunit

GCS light chain

gamma-ECS regulatory subunit

gamma-glutamylcysteine synthetase regulatory subunit

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W015600 2-Acetamidophenol 99.61% 否
HY-171705 KMS99220 99.48% 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-121523 MIND4-17 Activator 99.05% 否
HY-W015600S 2-Acetamidophenol-d3 99.48% 否
HY-172598 Keap1-Nrf2-IN-28 Inhibitor / 否
HY-181907 NBE5 / 否
HY-RS05334 GCLM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18936 Gclm Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25426 Gclm Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gclm NCBI NCBI:2730
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