2. Gene
  3. Grin1 - glutamate receptor, ionotropic, NMDA1 (zeta 1) Gene

Grin1 - glutamate receptor, ionotropic, NMDA1 (zeta 1) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1

基因 ID: 14810 | 基因类型: protein coding

关于 Grin1

功能概要

Enables several functions, including Calmodulin binding activity; cation binding activity; and ion channel activity. Involved in propylene metabolic process. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including dendritic spine; postsynaptic density membrane; and synaptic vesicle membrane. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Grin1 基因产物(8)

mRNA Protein Name
NM_001177656.2 NP_001171127.1 glutamate receptor ionotropic, NMDA 1 isoform 2
NM_001177657.2 NP_001171128.1 glutamate receptor ionotropic, NMDA 1 isoform 3 precursor
NM_001372558.1 NP_001359487.1 glutamate receptor ionotropic, NMDA 1 isoform 4 precursor
NM_001372559.1 NP_001359488.1 glutamate receptor ionotropic, NMDA 1 isoform 5 precursor
NM_001372560.1 NP_001359489.1 glutamate receptor ionotropic, NMDA 1 isoform 6 precursor
NM_001372561.1 NP_001359490.1 glutamate receptor ionotropic, NMDA 1 isoform 7 precursor
NM_001372562.1 NP_001359491.1 glutamate receptor ionotropic, NMDA 1 isoform 8 precursor
NM_008169.3 NP_032195.1 glutamate receptor ionotropic, NMDA 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NMDA glutamate receptor activity IDA
IDA: 通过直接分析推断
1374164 MGI
enables NMDA glutamate receptor activity IGI
IGI: 通过遗传相互作用推断
1374164 MGI
enables NMDA glutamate receptor activity IMP
IMP: 通过突变表型推断
8060614 MGI
enables calcium channel activity IDA
IDA: 通过直接分析推断
1374164 MGI
enables calcium channel activity IGI
IGI: 通过遗传相互作用推断
1374164 MGI
enables calcium ion binding IDA
IDA: 通过直接分析推断
15663482 MGI
enables calmodulin binding IDA
IDA: 通过直接分析推断
15663482 MGI
enables glycine binding IMP
IMP: 通过突变表型推断
12586454 MGI
enables monoatomic cation channel activity IGI
IGI: 通过遗传相互作用推断
7531804 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8595214 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
11754835 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
10481908 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
12040087 MGI
acts upstream of or within calcium ion homeostasis IDA
IDA: 通过直接分析推断
7907365 MGI
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
1532151 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
15576450 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
10963597 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: 通过突变表型推断
16101757 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
14645471 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
15003177 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
8060614 MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
16025111 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
17015831 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
17004940 MGI
acts upstream of or within long-term memory IMP
IMP: 通过突变表型推断
15003177 MGI
acts upstream of or within male mating behavior IMP
IMP: 通过突变表型推断
10481908 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
10700255 MGI
acts upstream of or within monoatomic cation transport IGI
IGI: 通过遗传相互作用推断
7531804 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
17077143 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17077143 MGI
acts upstream of or within neuromuscular process IMP
IMP: 通过突变表型推断
8313466 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: 通过突变表型推断
8060614 MGI
acts upstream of or within olfactory learning IMP
IMP: 通过突变表型推断
10700255 MGI
acts upstream of or within pons maturation IMP
IMP: 通过突变表型推断
8313466 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
17803966 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7907365 MGI
acts upstream of or within prepulse inhibition IMP
IMP: 通过突变表型推断
15265649 MGI
involved in propylene metabolic process IDA
IDA: 通过直接分析推断
21795692 MGI
acts upstream of or within protein localization to postsynaptic membrane IMP
IMP: 通过突变表型推断
12676993 MGI
acts upstream of or within regulation of axonogenesis IMP
IMP: 通过突变表型推断
15745956 MGI
acts upstream of or within regulation of cell communication IMP
IMP: 通过突变表型推断
16299502 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
15745956 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
10818139 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
8060614 MGI
acts upstream of or within regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10479699 MGI
acts upstream of or within regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
16906136 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
15576450 MGI
acts upstream of or within regulation of respiratory gaseous exchange IMP
IMP: 通过突变表型推断
8313466 MGI
acts upstream of or within regulation of synapse assembly IMP
IMP: 通过突变表型推断
12657691 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
8980238 MGI
acts upstream of or within response to amphetamine IGI
IGI: 通过遗传相互作用推断
21368124 MGI
acts upstream of or within response to amphetamine IMP
IMP: 通过突变表型推断
15467708 MGI
acts upstream of or within response to morphine IMP
IMP: 通过突变表型推断
18423864 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
12832526 MGI
acts upstream of or within social behavior IMP
IMP: 通过突变表型推断
10481908 MGI
acts upstream of or within startle response IMP
IMP: 通过突变表型推断
10818139 MGI
acts upstream of or within suckling behavior IMP
IMP: 通过突变表型推断
8313466 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
8313466 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7907365 MGI
acts upstream of or within visual learning IGI
IGI: 通过遗传相互作用推断
9054942 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
8980238 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NMDA selective glutamate receptor complex IDA
IDA: 通过直接分析推断
12008020 MGI
part of NMDA selective glutamate receptor complex IPI
IPI: 通过物理相互作用推断
9003035 MGI
located in cell surface IDA
IDA: 通过直接分析推断
17229826 MGI
located in cell surface IMP
IMP: 通过突变表型推断
17229826 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12414093 MGI
located in dendrite IDA
IDA: 通过直接分析推断
23395379 MGI
located in dendrite IMP
IMP: 通过突变表型推断
17229826 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
15663482 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16814779 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19726645 MGI
located in membrane IDA
IDA: 通过直接分析推断
8840015 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
1532151 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
15317856 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
19726645 MGI
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
11754836 MGI
located in synapse IDA
IDA: 通过直接分析推断
14645471 MGI
located in synaptic membrane IDA
IDA: 通过直接分析推断
26041915 MGI
located in synaptic vesicle IDA
IDA: 通过直接分析推断
10846156 MGI
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
29490264 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate receptor ionotropic, NMDA 1

N-methyl-D-aspartate receptor subunit NR1

glutamate [NMDA] receptor subunit zeta-1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05803 GRIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05754 GPRIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20948 Grin1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27465 Grin1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grin1 NCBI NCBI:2902
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