DGKG - diacylglycerol kinase gamma Gene

中文名称：二酰甘油激酶γ

种属: Homo sapiens

同用名: DAGK3; DGK-GAMMA

关于 DGKG

功能概要

该基因编码的酶是二酰基甘油激酶 I 型亚家族的成员，参与脂质代谢。这些酶通过催化甘油二酯的磷酸化产生磷脂酸，甘油二酯是一种基本的脂质第二信使，可激活多种蛋白质，包括蛋白激酶 C 同种型、Ras 鸟苷酸释放蛋白和一些瞬时受体电位通道。二酰甘油激酶γ与细胞周期调节和白血病细胞中巨噬细胞分化的负调节有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These Enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]