Smad4 - SMAD family member 4 Gene

种属: Mus musculus

同用名: DPC4; Madh4; D18Wsu70e

关于 Smad4

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Collagen binding activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; heart development; and positive regulation of protein modification process. Acts upstream of or within several processes, including animal organ development; positive regulation of gonadotropin secretion; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and respiratory system. Used to study juvenile polyposis syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ Cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (Smad Family member 4). [provided by Alliance of Genome Resources, Apr 2022]