2. Gene
  3. LPAR1 - lysophosphatidic acid receptor 1 Gene

LPAR1 - lysophosphatidic acid receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酸受体 1

种属: Homo sapiens

同用名: EDG2; LPA1; VZG1; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3

基因 ID: 1902 | 基因类型: protein coding

关于 LPAR1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,873,263-111,038,998 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 8.1) and 22 other tissues.

功能概要

由该基因编码的完整膜蛋白是来自称为 EDG 受体的组的溶血磷脂酸 (LPA) 受体。这些受体是 G 蛋白偶联受体超家族的成员。 LPA 利用细胞信号传导，EDG 受体介导多种生物学功能，包括增殖、血小板聚集、平滑肌收缩、神经母细胞瘤细胞分化抑制、趋化性和肿瘤细胞侵袭。已经为该基因鉴定了许多编码几种不同同种型的转录物变体。[RefSeq 提供，2020 年 10 月]

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

LPAR1 基因产物(77)

mRNA Protein Name
NM_001351404.2 NP_001338333.1 lysophosphatidic acid receptor 1 isoform a
NM_001387507.1 NP_001374436.1 lysophosphatidic acid receptor 1 isoform a
NM_001351420.2 NP_001338349.1 lysophosphatidic acid receptor 1 isoform a
NM_001351419.2 NP_001338348.1 lysophosphatidic acid receptor 1 isoform a
NM_001387475.1 NP_001374404.1 lysophosphatidic acid receptor 1 isoform a
NM_001387479.1 NP_001374408.1 lysophosphatidic acid receptor 1 isoform a
NM_001387489.1 NP_001374418.1 lysophosphatidic acid receptor 1 isoform a
NM_001387472.1 NP_001374401.1 lysophosphatidic acid receptor 1 isoform a
NM_001387511.1 NP_001374440.1 lysophosphatidic acid receptor 1 isoform a
NM_001351406.2 NP_001338335.1 lysophosphatidic acid receptor 1 isoform a
NM_001387496.1 NP_001374425.1 lysophosphatidic acid receptor 1 isoform a
NM_001351402.2 NP_001338331.1 lysophosphatidic acid receptor 1 isoform a
NM_001387486.1 NP_001374415.1 lysophosphatidic acid receptor 1 isoform a
NM_001351412.2 NP_001338341.1 lysophosphatidic acid receptor 1 isoform a
NM_001387505.1 NP_001374434.1 lysophosphatidic acid receptor 1 isoform a
NM_001387504.1 NP_001374433.1 lysophosphatidic acid receptor 1 isoform a
NM_001351400.2 NP_001338329.1 lysophosphatidic acid receptor 1 isoform a
NM_001351408.2 NP_001338337.1 lysophosphatidic acid receptor 1 isoform a
NM_001351418.2 NP_001338347.1 lysophosphatidic acid receptor 1 isoform a
NM_001387488.1 NP_001374417.1 lysophosphatidic acid receptor 1 isoform a
NM_001387493.1 NP_001374422.1 lysophosphatidic acid receptor 1 isoform a
NM_001387473.1 NP_001374402.1 lysophosphatidic acid receptor 1 isoform a
NM_001387498.1 NP_001374427.1 lysophosphatidic acid receptor 1 isoform a
NM_001387514.1 NP_001374443.1 lysophosphatidic acid receptor 1 isoform a
NM_001387490.1 NP_001374419.1 lysophosphatidic acid receptor 1 isoform a
NM_001387521.1 NP_001374450.1 lysophosphatidic acid receptor 1 isoform c
XM_047422903.1 XP_047278859.1 lysophosphatidic acid receptor 1 isoform X1
NM_001387471.1 NP_001374400.1 lysophosphatidic acid receptor 1 isoform a
NM_001351411.2 NP_001338340.1 lysophosphatidic acid receptor 1 isoform a
NM_001387487.1 NP_001374416.1 lysophosphatidic acid receptor 1 isoform a
NM_001387480.1 NP_001374409.1 lysophosphatidic acid receptor 1 isoform a
NM_001387501.1 NP_001374430.1 lysophosphatidic acid receptor 1 isoform a
NM_001387492.1 NP_001374421.1 lysophosphatidic acid receptor 1 isoform a
NM_001351401.2 NP_001338330.1 lysophosphatidic acid receptor 1 isoform a
NM_001387481.1 NP_001374410.1 lysophosphatidic acid receptor 1 isoform a
NM_057159.4 NP_476500.1 lysophosphatidic acid receptor 1 isoform a
NM_001387484.1 NP_001374413.1 lysophosphatidic acid receptor 1 isoform a
NM_001387482.1 NP_001374411.1 lysophosphatidic acid receptor 1 isoform a
NM_001351416.2 NP_001338345.1 lysophosphatidic acid receptor 1 isoform a
NM_001351403.2 NP_001338332.1 lysophosphatidic acid receptor 1 isoform a
NM_001387513.1 NP_001374442.1 lysophosphatidic acid receptor 1 isoform a
NM_001351415.2 NP_001338344.1 lysophosphatidic acid receptor 1 isoform a
NM_001387478.1 NP_001374407.1 lysophosphatidic acid receptor 1 isoform a
NM_001387519.1 NP_001374448.1 lysophosphatidic acid receptor 1 isoform c
NM_001387508.1 NP_001374437.1 lysophosphatidic acid receptor 1 isoform a
NM_001351405.2 NP_001338334.1 lysophosphatidic acid receptor 1 isoform a
NM_001387483.1 NP_001374412.1 lysophosphatidic acid receptor 1 isoform a
NM_001387517.1 NP_001374446.1 lysophosphatidic acid receptor 1 isoform b
NM_001351417.2 NP_001338346.1 lysophosphatidic acid receptor 1 isoform a
NM_001351397.2 NP_001338326.1 lysophosphatidic acid receptor 1 isoform a
NM_001387506.1 NP_001374435.1 lysophosphatidic acid receptor 1 isoform a
NM_001387512.1 NP_001374441.1 lysophosphatidic acid receptor 1 isoform a
NM_001387470.1 NP_001374399.1 lysophosphatidic acid receptor 1 isoform a
NM_001351407.2 NP_001338336.1 lysophosphatidic acid receptor 1 isoform a
NM_001387510.1 NP_001374439.1 lysophosphatidic acid receptor 1 isoform a
NM_001387516.1 NP_001374445.1 lysophosphatidic acid receptor 1 isoform b
NM_001387497.1 NP_001374426.1 lysophosphatidic acid receptor 1 isoform a
NM_001351413.2 NP_001338342.1 lysophosphatidic acid receptor 1 isoform a
NM_001351409.2 NP_001338338.1 lysophosphatidic acid receptor 1 isoform a
NM_001351399.2 NP_001338328.1 lysophosphatidic acid receptor 1 isoform a
NM_001387494.1 NP_001374423.1 lysophosphatidic acid receptor 1 isoform a
NM_001387515.1 NP_001374444.1 lysophosphatidic acid receptor 1 isoform a
NM_001351414.2 NP_001338343.1 lysophosphatidic acid receptor 1 isoform a
NM_001401.5 NP_001392.2 lysophosphatidic acid receptor 1 isoform a
NM_001387476.1 NP_001374405.1 lysophosphatidic acid receptor 1 isoform a
NM_001387477.1 NP_001374406.1 lysophosphatidic acid receptor 1 isoform a
NM_001387485.1 NP_001374414.1 lysophosphatidic acid receptor 1 isoform a
NM_001387491.1 NP_001374420.1 lysophosphatidic acid receptor 1 isoform a
NM_001387495.1 NP_001374424.1 lysophosphatidic acid receptor 1 isoform a
NM_001387518.1 NP_001374447.1 lysophosphatidic acid receptor 1 isoform b
NM_001387474.1 NP_001374403.1 lysophosphatidic acid receptor 1 isoform a
NM_001387503.1 NP_001374432.1 lysophosphatidic acid receptor 1 isoform a
NM_001387502.1 NP_001374431.1 lysophosphatidic acid receptor 1 isoform a
NM_001351398.2 NP_001338327.1 lysophosphatidic acid receptor 1 isoform a
NM_001387520.1 NP_001374449.1 lysophosphatidic acid receptor 1 isoform c
NM_001351410.2 NP_001338339.1 lysophosphatidic acid receptor 1 isoform a
NM_001387509.1 NP_001374438.1 lysophosphatidic acid receptor 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lysophosphatidic acid binding IDA
IDA: 通过直接分析推断
9070858 GOA
enables lysophosphatidic acid receptor activity IDA
IDA: 通过直接分析推断
19306925 GOA
enables lysophosphatidic acid receptor activity IMP
IMP: 通过突变表型推断
9070858 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19306925 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19306925 GOA
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
19733258 GOA
involved in negative regulation of cilium assembly IDA
IDA: 通过直接分析推断
31204173 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19733258 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: 通过表达模式推断
12761501 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19306925 GOA
colocalizes with endocytic vesicle IDA
IDA: 通过直接分析推断
19306925 GOA
located in endosome IDA
IDA: 通过直接分析推断
19306925 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19306925 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LPAR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (67 - 311)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 1

LPA receptor 1

LPA-1

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2

lysophosphatidic acid receptor Edg-2

ventricular zone gene 1

LPAR1 抗体

目录号 产品名 应用 反应物种
HY-P83630 EDG2 Antibody (YA3375) WB, IHC-P, ICC/IF, FC, IP Human

关联疾病

疾病名称 别名
Spinal Stenosis

Lumbar Spinal Stenosis

Cervical Spinal Stenosis

Spinal Stenosis Of Lumbar Region

Spinal Stenosis In Cervical Region

Spinal Canal Stenosis
Hypotrichosis 8

HYPT8

Lah3

Hypotrichosis, Localized, Autosomal Recessive 3

Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis

Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis

Hypotrichosis Localized Autosomal Recessive 3

Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis

ARWH1

Hypotrichosis, Type 8
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction

Chronic Intestinal Pseudo-Obstruction

Cipo

Neuronal Intestinal Dysplasia

Hollow Visceral Myopathy

Familial Visceral Neuropathy

Paralytic Ileus

Intestinal Pseudoobstruction

Chronic Idiopathic Intestinal Pseudo-Obstruction

Ciip

Congenital Short Bowel Syndrome

Enteric Neuropathy

Familial Visceral Myopathy

Ipo

Pseudo-Obstruction Of Intestine

Pseudointestinal Obstruction Syndrome

Pseudoobstructive Syndrome

Congenital Idiopathic Intestinal Pseudoobstruction

Visceral Myopathy, Familial
Pulmonary Fibrosis

Fibrosis Of Lung
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Fibrosclerosis Of Breast

Fibrosis Of The Breast

Breast Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16039 AM095 Antagonist 99.72% 否
HY-15706 H2L 5765834 Antagonist 98.66% 否
HY-117444 ONO-9780307 Inhibitor 99.94% 否
HY-117959 TAK-615 Inhibitor 98.07% 否
HY-115450 ONO-0300302 Antagonist 98.02% 否
HY-124072 HL001 Antagonist 98.90% 否
HY-148291 BrP-LPA sodium Antagonist / 否
HY-178845 Decyl phosphate Modulator / 否
HY-181931 Autotaxin-IN-8 Inhibitor / 否
HY-W725737 BrP-LPA Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LPAR1 VGNC VGNC:63261
Bos taurus LPAR1 VGNC VGNC:30955
Mus musculus LPAR1 MGD MGI:108429
Canis familiaris LPAR1 VGNC VGNC:42742
Rattus norvegicus LPAR1 RGD RGD:620563
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