2. Gene
  3. Kdm5a - lysine (K)-specific demethylase 5A Gene

Kdm5a - lysine (K)-specific demethylase 5A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: RBP2; Rbbp2; Jarid1a

基因 ID: 214899 | 基因类型: protein coding

关于 Kdm5a

功能概要

Enables chromatin DNA binding activity and transcription coactivator activity. Involved in circadian regulation of gene expression and negative regulation of histone deacetylase activity. Acts upstream of or within histone H3-K4 demethylation and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in ankylosing spondylitis. Orthologous to human KDM5A (lysine demethylase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm5a 基因产物(1)

mRNA Protein Name
NM_145997.2 NP_666109.2 lysine-specific demethylase 5A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
18483221 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
20064375 MGI
enables enzyme inhibitor activity IDA
IDA: 通过直接分析推断
21960634 MGI
enables histone H3K4 demethylase activity IMP
IMP: 通过突变表型推断
18483221 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20064375 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
21960634 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
21960634 MGI
involved in facultative heterochromatin formation IDA
IDA: 通过直接分析推断
20064375 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18483221 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18483221 MGI
part of protein-DNA complex IDA
IDA: 通过直接分析推断
18483221 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lysine-specific demethylase 5A

RBBP-2

[histone H3]-trimethyl-L-lysine(4) demethylase 5A

histone demethylase JARID1A

jumonji, AT rich interactive domain 1A (Rbp2 like)

jumonji/ARID domain-containing protein 1A

retinoblastoma binding protein 2

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100421 CPI-455 Inhibitor 98.95% 否
HY-102047B KDOAM-25 citrate Inhibitor 98.56% 否
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% 否
HY-100014 KDM5A-IN-1 Inhibitor 99.64% 否
HY-100421A CPI-455 hydrochloride Inhibitor 99.95% 否
HY-119397A KDM5-C49 hydrochloride Inhibitor 98.22% 否
HY-100624 Ryuvidine Inhibitor 99.23% 否
HY-100764 YUKA1 Inhibitor 99.15% 否
HY-144501 D18 98.79% 否
HY-102047 KDOAM-25 Inhibitor / 否
HY-123419 CPI-4203 Inhibitor 99.0% 否
HY-RS07218 KDM5A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-102047A KDOAM-25 trihydrochloride Inhibitor / 否
HY-119397 KDM5-C49 Inhibitor / 否
HY-136682 N19-0881 Inhibitor / 否
HY-RS16664 Kdm5a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23099 Kdm5a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kdm5a NCBI NCBI:5927
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