1. Gene
  2. PELI3 - pellino E3 ubiquitin protein ligase family member 3 Gene

PELI3 - pellino E3 ubiquitin protein ligase family member 3 Gene

中文名称:pellino E3 泛素蛋白连接酶家族成员 3

种属: Homo sapiens

基因 ID: 246330 | 基因类型: protein coding

关于 PELI3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,466,327-66,477,337 (from NCBI)

This gene has 9 transcripts (splice variants), 179 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 6.1), ovary (RPKM 4.8) and 24 other tissues.

功能概要

该基因编码的蛋白质是先天免疫反应通路中的支架蛋白和中间信号蛋白。编码的蛋白质有助于将免疫反应信号从 Toll 样受体传递到 IRAK1/TRAF6 复合物。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2011 年 7 月]

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PELI3 基因产物(4)

mRNA Protein Name
NM_001098510.2 NP_001091980.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
NM_001243135.2 NP_001230064.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 3
NM_001243136.2 NP_001230065.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 4
NM_145065.3 NP_659502.2 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12874243 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PELI3 蛋白结构

Pellino

Pellino: Pellino (76 - 469)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase pellino homolog 3

RING-type E3 ubiquitin transferase pellino homolog 3

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PELI3 RGD RGD:1305989
Felis catus PELI3 VGNC VGNC:81961
Bos taurus PELI3 VGNC VGNC:32742
Macaca mulatta PELI3 VGNC VGNC:75886
Mus musculus PELI3 MGD MGI:1924963
Canis familiaris PELI3 VGNC VGNC:44416