2. Gene
  3. Cyp2e1 - cytochrome P450, family 2, subfamily e, polypeptide 1 Gene

Cyp2e1 - cytochrome P450, family 2, subfamily e, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cyp2e

基因 ID: 25086 | 基因类型: protein coding

关于 Cyp2e1

功能概要

Enables HSP70 protein binding activity and HSP90 protein binding activity. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Is intrinsic component of endoplasmic reticulum membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system Cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (Cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp2e1 基因产物(1)

mRNA Protein Name
NM_031543.2 NP_113731.2 cytochrome P450 2E1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp70 protein binding IDA
IDA: 通过直接分析推断
19401463 RGD
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
19401463 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to 3-methylcholanthrene IEP
IEP: 通过表达模式推断
19889059 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16337197 RGD
involved in response to ozone IEP
IEP: 通过表达模式推断
9571988 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
21170329 RGD
involved in triglyceride metabolic process IMP
IMP: 通过突变表型推断
20116195 RGD
involved in xenobiotic metabolic process IMP
IMP: 通过突变表型推断
21187827 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
8809087 RGD
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
19401463 RGD
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
19401463 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytochrome P450 2E1

4-nitrophenol 2-hydroxylase

CYPIIE1

P450-J

P450RLM6

cytochrome P450 subfamily 2e1 (ethanol-inducible)

cytochrome P450, subfamily 2E, polypeptide 1

cytochrome P450-J

cytochrome P450RLM6

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N6972 Cepharanthine 99.87% 是
HY-B0876 Fomepizole Inhibitor 99.78% 是
HY-B0876A Fomepizole hydrochloride Inhibitor 99.85% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-129105 Clomethiazole 99.35% Phase 3
HY-A0296 Chlormethiazole hydrochloride Inhibitor 99.94% Phase 3
Pre-clinical Phase
生物活性分子 (33)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y0698 Thioacetamide 98.0% 否
HY-N0692 Schisandrol B 99.92% 否
HY-W013268 (S)-(+)-N-3-Benzylnirvanol Inhibitor 99.76% 否
HY-D0848 N,N'-Methylenebisacrylamide Activator 99.98% 否
HY-117026 LKY-047 Inhibitor 99.94% 否
HY-W042193 2-Piperidone 99.89% 否
HY-W016221 6-Hydroxy Chlorzoxazone 99.02% 否
HY-Y0110 2-Naphthol 99.91% 否
HY-W072025 CYP2E1-IN-1 99.95% 否
HY-N4110 Friedelin Inhibitor 99.0% 否
HY-116228 Cadrofloxacin Inhibitor 98.21% 否
HY-N1407 Polygalaxanthone III Inhibitor 99.28% 否
HY-B1462S Chlorzoxazone-d3 Modulator 99.88% 否
HY-W458364 1-(Isothiazol-3-yl)ethan-1-one Inhibitor 99.26% 否
HY-N5132 (-)-Fenchone 98.0% 否
HY-N8382 Chalepensin Inhibitor 98.98% 否
HY-Y0110S1 2-Naphthol-d7 99.37% 否
HY-B1351 Bilberry Extract / 否
HY-N0592 Demethyleneberberine ≥98.0% 否
HY-N2586 Tenuifoliside C 99.57% 否
HY-RS03463 CYP2E1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16890 Cyp2e1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-W067374 Aripiprazole impurity 38 / 否
HY-146177 CYP3A4 enzyme-IN-1 Inhibitor / 否
HY-19435 GYKI-47261 / 否
HY-19435A GYKI-47261 dihydrochloride / 否
HY-N17737 Floramanoside F / 否
HY-W140208 3-Phenylthiophene Inhibitor / 否
HY-W710827 N,N'-Methylenebisacrylamide-d6 / 否
HY-W724345 Fomepizole-d2 / 否
HY-Y0110S 2-Naphthol-d8 / 否
HY-119403 4-Phenyl-1,2,3-thiadiazole Inhibitor 99.98% 否
HY-RS23332 Cyp2e1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp2e1 NCBI NCBI:1571
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