2. Gene
  3. Grk2 - G protein-coupled receptor kinase 2 Gene

Grk2 - G protein-coupled receptor kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BARK1; GRK-2; Adrbk1

基因 ID: 25238 | 基因类型: protein coding

关于 Grk2

功能概要

Enables several functions, including Opioid Receptor binding activity; protein kinase activity; and scaffold protein binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of G protein-coupled receptor signaling pathway; and negative regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; caveola; and dendrite. Used to study hyperglycemia; impotence; and limb ischemia. Biomarker of Parkinson's disease; congestive heart failure; hypertension; and portal hypertension. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Grk2 基因产物(1)

mRNA Protein Name
NM_012776.2 NP_036908.2 beta-adrenergic receptor kinase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
26228571 RGD
enables G protein-coupled receptor kinase activity IDA
IDA: 通过直接分析推断
1403099 RGD
enables beta-adrenergic receptor kinase activity IDA
IDA: 通过直接分析推断
1403099 RGD
enables delta-type opioid receptor binding IPI
IPI: 通过物理相互作用推断
28381559 RGD
enables kappa-type opioid receptor binding IPI
IPI: 通过物理相互作用推断
27865836 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15626685 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
28162981 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
26228571 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12021252 RGD
involved in G protein-coupled receptor signaling pathway IEP
IEP: 通过表达模式推断
29081032 RGD
involved in cellular response to catecholamine stimulus IEP
IEP: 通过表达模式推断
26849467 RGD
involved in cellular response to chemokine IDA
IDA: 通过直接分析推断
23221335 RGD
involved in cellular response to epidermal growth factor stimulus IMP
IMP: 通过突变表型推断
24018045 RGD
involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
27865836 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
23467820 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IEP
IEP: 通过表达模式推断
29905975 RGD
involved in cellular response to rapamycin IEP
IEP: 通过表达模式推断
26228571 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
18223549 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
17908240 RGD
involved in follicle-stimulating hormone signaling pathway IDA
IDA: 通过直接分析推断
16899567 RGD
involved in maintenance of protein location in nucleus IMP
IMP: 通过突变表型推断
28759639 RGD
involved in negative regulation of D-glucose import IMP
IMP: 通过突变表型推断
26660861 RGD
involved in negative regulation of G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
1403099 RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
30075183 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
26849467 RGD
involved in negative regulation of cellular response to insulin stimulus IMP
IMP: 通过突变表型推断
23913704 RGD
involved in negative regulation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
23690069 RGD
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
26660861 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
26660861 RGD
involved in oligodendrocyte differentiation IEP
IEP: 通过表达模式推断
24613411 RGD
involved in oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
24613411 RGD
involved in positive regulation of catecholamine secretion IDA
IDA: 通过直接分析推断
18223549 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
28975565 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
27862165 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
28193640 RGD
involved in positive regulation of muscle cell apoptotic process IMP
IMP: 通过突变表型推断
26631573 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
24018045 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
28882814 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
1403099 RGD
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
23690069 RGD
involved in regulation of inositol trisphosphate biosynthetic process IMP
IMP: 通过突变表型推断
20705669 RGD
involved in response to caloric restriction IEP
IEP: 通过表达模式推断
23073237 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
16337875 RGD
involved in response to leptin IEP
IEP: 通过表达模式推断
23073237 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
23913704 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
16478977 RGD
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
16478977 RGD
involved in vasodilation IMP
IMP: 通过突变表型推断
23913704 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
16899567 RGD
located in axon IDA
IDA: 通过直接分析推断
1403099 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16899567 RGD
located in caveola IDA
IDA: 通过直接分析推断
15626685 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
1403099 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
1403099 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
1403099 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
1403099 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
1403099 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

beta-adrenergic receptor kinase 1

adrenergic receptor kinase, beta 1

adrenergic, beta, receptor kinase 1

beta-ARK-1

beta-adrenergic receptor kinase 1 beta ARK1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0492 Paroxetine hydrochloride Inhibitor 99.98% 否
HY-B0492A Paroxetine hydrochloride hemihydrate Inhibitor 99.96% 否
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103045 CMPD101 Inhibitor 98.96% 否
HY-109562A CCG258208 hydrochloride 98.05% 否
HY-18991 CCG215022 Inhibitor 99.79% 否
HY-156863 GRK2 Inhibitor 2 Inhibitor 99.92% 否
HY-121983 CAY10594 Modulator 98.64% 否
HY-W013411A Locostatin Inhibitor 99.88% 否
HY-18990 GSK180736A Inhibitor 98.81% 否
HY-47573 CCG273441 Inhibitor 98.78% 否
HY-123538 GRK2 Inhibitor 1 Inhibitor 98.06% 否
HY-139690 CCG258747 Inhibitor 98.96% 否
HY-P1396A GRK2i TFA Inhibitor 99.89% 否
HY-129118 Takeda103A Inhibitor 98.69% 否
HY-177948 GRK2 degrader-1 Degrader / 否
HY-RS05813 GRK2 Human Pre-designed siRNA Set A Inhibitor / 否
HY-109562 CCG258208 Inhibitor / 否
HY-103045A CMPD101 hydrochloride Inhibitor / 否
HY-150022 GRK5-IN-4 Inhibitor / 否
HY-150039 CCG-271423 Inhibitor / 否
HY-119232 GSK466317A Inhibitor / 否
HY-120168 CCG 258001 Inhibitor / 否
HY-120718 CCG 224061 Inhibitor / 否
HY-P1396 GRK2i Inhibitor / 否
HY-123254 CCG-224406 Inhibitor / 否
HY-B0492S1 Paroxetine-d4 hydrochloride Inhibitor 99.16% 否
HY-168971 Paeoniflorin-6′-O-benzene sulfonate Inhibitor / 否
HY-118046 GSK2163632A Inhibitor / 否
HY-179707 GRL-03022 Inhibitor / 否
HY-155099 FGH31 / 否
HY-180583 GRK5-IN-5 Inhibitor / 否
HY-RS23286 Grk2 Rat Pre-designed siRNA Set A Inhibitor / 否
HY-RS16845 Grk2 Mouse Pre-designed siRNA Set A Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grk2 NCBI NCBI:156
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