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  2. PDE7B - phosphodiesterase 7B Gene

PDE7B - phosphodiesterase 7B Gene

中文名称:磷酸二酯酶 7B

种属: Homo sapiens

同用名: bA472E5.1

基因 ID: 27115 | 基因类型: protein coding

关于 PDE7B

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:135,851,701-136,195,574 (from NCBI)

This gene has 3 transcripts (splice variants), 174 orthologues and 20 paralogues. Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.5) and 22 other tissues.

功能概要

3',5'-环核苷酸 cAMP 和 cGMP 在多种信号转导途径中充当第二信使。 3',5'-环核苷酸磷酸二酯酶 (PDE) 催化 cAMP 和 cGMP 水解为相应的 5'-单磷酸酯,并提供下调 cAMP 和 cGMP 信号传导的机制。该基因编码一种 cAMP 特异性磷酸二酯酶,它是环核苷酸磷酸二酯酶家族的一员。[RefSeq 提供,2009 年 4 月]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

PDE7B 基因产物(1)

mRNA Protein Name
NM_018945.4 NP_061818.1 cAMP-specific 3',5'-cyclic phosphodiesterase 7B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
10814504 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
10814504 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PDE7B 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (172 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
蛋白主名 其他名称

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase

关联疾病

疾病名称 别名
Dyslexia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDE7B MGD MGI:1352752
Bos taurus PDE7B VGNC VGNC:32686
Macaca mulatta PDE7B VGNC VGNC:75923
Rattus norvegicus PDE7B RGD RGD:621016
Canis familiaris PDE7B VGNC VGNC:44364
Felis catus PDE7B VGNC VGNC:68765