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  3. Parp4 - poly (ADP-ribose) polymerase family, member 4 Gene

Parp4 - poly (ADP-ribose) polymerase family, member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族，成员 4

种属: Mus musculus

同用名: PH5P; p193; ARTD4; Gm743; PARPL; VPARP; PARP-4; VAULT3; Adprtl1; C030027K23Rik; E230037B21Rik

基因 ID: 328417 | 基因类型: protein coding

关于 Parp4

Chromosome 14: 56,813,076-56,897,251 forward strand.GRCm39:CM001007.3

This gene has 2 transcripts (splice variants), 186 orthologues, 11 paralogues and is associated with 6 phenotypes. Ubiquitous expression in bladder adult (RPKM 5.9), placenta adult (RPKM 4.9) and 26 other tissues.

功能概要

预测该基因编码的蛋白可启动 NAD+ ADP-核糖基转移酶活性；酶结合活性；和蛋白质 ADP-核糖基酶活性。预计参与多个过程，包括炎症反应；蛋白质单-ADP-核糖基化；和端粒酶活性的调节。预测作用于蛋白质 ADP-核糖基化的上游或内部。预测位于胞质溶胶和纺锤体微管中。与人类 PARP4（聚（ADP-核糖）聚合酶家族成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Predicted to be involved in several processes, including inflammatory response; protein mono-ADP-ribosylation; and regulation of Telomerase activity. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in cytosol and spindle microtubule. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Parp4 基因产物(1)

mRNA Protein Name
NM_001145978.2 NP_001139450.2 protein mono-ADP-ribosyltransferase PARP4

Parp4 蛋白结构

BRCT

BRCT: cl00038 (4 - 87)

parp_like

parp_like: cd01437 (243 - 556)

VIT

VIT: pfam08487 (615 - 725)

VWA

VWA: smart00327 (869 - 1025)

Drf_FH1

Drf_FH1: cl25521 (1371 - 1607)

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  • 1969 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP4

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase)-like 1

ADP-ribosyltransferase diphtheria toxin-like 4

mVparp

poly [ADP-ribose] polymerase 4

vault poly(ADP-ribose) polymerase

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.41% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136979 RBN012759 Inhibitor 99.33% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-150207 RBN-3143 Inhibitor 99.29% 否
HY-148754 PARP10-IN-3 Inhibitor 98.72% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-W294889 OUL245 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parp4 NCBI NCBI:143
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