1. Gene
  2. KCNJ9 - potassium inwardly rectifying channel subfamily J member 9 Gene

KCNJ9 - potassium inwardly rectifying channel subfamily J member 9 Gene

中文名称:钾内向整流通道亚家族 J 成员 9

种属: Homo sapiens

同用名: GIRK3; KIR3.3

基因 ID: 3765 | 基因类型: protein coding

关于 KCNJ9

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,081,538-160,090,563 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 8.9).

功能概要

钾通道存在于大多数哺乳动物细胞中,它们参与广泛的生理反应。该基因编码的蛋白是一种完整的膜蛋白和内向整流型钾通道。编码的蛋白质更倾向于让钾流入细胞而不是流出细胞,由 G 蛋白控制。它与另一个 G 蛋白激活的钾通道结合形成异多聚体成孔复合物。[RefSeq 提供,2008 年 7 月]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated Potassium Channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

KCNJ9 基因产物(1)

mRNA Protein Name
NM_004983.3 NP_004974.2 G protein-activated inward rectifier potassium channel 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12297500 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCNJ9 蛋白结构

IRK

IRK: Inward rectifier potassium channel (25 - 347)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

G protein-activated inward rectifier potassium channel 3

G protein-coupled inward rectifier potassium channel

关联疾病

疾病名称 别名
Deafness, Autosomal Dominant 7

DFNA7

Autosomal Dominant Nonsyndromic Deafness 7

Autosomal Dominant Deafness 7

Deafness, Autosomal Dominant, 7

Deafness, Autosomal Dominant, Type 7

Vitreoretinal Degeneration, Snowflake Type

Snowflake Vitreoretinal Degeneration

SVD

Snowflake Degeneration In Hereditary Vitreoretinal Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus KCNJ9 VGNC VGNC:30464
Canis familiaris KCNJ9 VGNC VGNC:42269
Felis catus KCNJ9 VGNC VGNC:67918
Macaca mulatta KCNJ9 VGNC VGNC:106397
Rattus norvegicus KCNJ9 RGD RGD:621440
Mus musculus KCNJ9 MGD MGI:108007