MYH10 - myosin heavy chain 10 Gene

中文名称：肌球蛋白重链 10

种属: Homo sapiens

同用名: NMMHCB; NMMHC-IIB

基因 ID: 4628 | 基因类型: protein coding

关于 MYH10

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,474,212-8,631,345 (from NCBI)

This gene has 32 transcripts (splice variants), 212 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues.

功能概要

该基因编码肌球蛋白超家族的一个成员。该蛋白质代表常规的非肌肉肌球蛋白；它不应与非常规肌球蛋白 10 (MYO10) 混淆。肌球蛋白是肌动蛋白依赖性运动蛋白，具有多种功能，包括调节胞质分裂、细胞运动和细胞极性。该基因的突变与大脑和心脏的 May-Hegglin 异常和发育缺陷有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the Myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYH10 基因产物(4)

mRNA	Protein	Name
NM_001256012.3	NP_001242941.1	myosin-10 isoform 1
NM_001256095.2	NP_001243024.1	myosin-10 isoform 3
NM_001375266.1	NP_001362195.1	myosin-10 isoform 4
NM_005964.5	NP_005955.3	myosin-10 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ADP binding	IDA IDA: 通过直接分析推断	15845534	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	15845534	GOA
enables RNA stem-loop binding	IDA IDA: 通过直接分析推断	20603131	GOA
enables actin filament binding	IDA IDA: 通过直接分析推断	15845534	GOA
contributes to actin filament binding	IMP IMP: 通过突变表型推断	24072716	GOA
enables mRNA 5'-UTR binding	IDA IDA: 通过直接分析推断	20603131	GOA
enables microfilament motor activity	IDA IDA: 通过直接分析推断	15845534	GOA
contributes to microfilament motor activity	IMP IMP: 通过突变表型推断	24072716	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7542763	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within actin filament-based movement	IDA IDA: 通过直接分析推断	15845534	GOA
involved in actomyosin structure organization	IMP IMP: 通过突变表型推断	24072716	GOA
acts upstream of or within mitotic cytokinesis	IDA IDA: 通过直接分析推断	15774463	GOA
involved in positive regulation of protein secretion	IMP IMP: 通过突变表型推断	20603131	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actomyosin	IDA IDA: 通过直接分析推断	24072716	GOA
located in cell cortex	IDA IDA: 通过直接分析推断	7699007	GOA
located in cleavage furrow	IDA IDA: 通过直接分析推断	7699007	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	7699007	GOA
located in cytosol	IMP IMP: 通过突变表型推断	20603131	GOA
located in midbody	IDA IDA: 通过直接分析推断	11029059	GOA
part of myosin II complex	IDA IDA: 通过直接分析推断	24072716	GOA
located in myosin II filament	IDA IDA: 通过直接分析推断	24072716	GOA
is active in postsynaptic actin cytoskeleton	IDA IDA: 通过直接分析推断	30123108	GOA
is active in postsynaptic actin cytoskeleton	IMP IMP: 通过突变表型推断	30123108	GOA
located in stress fiber	IDA IDA: 通过直接分析推断	7699007	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYH10 蛋白结构

Myosin_N

Myosin_head

Myosin_tail_1

0
400
800
1200
1600
1976 a.a.

蛋白主名

其他名称

myosin-10

myosin heavy chain, nonmuscle type B

MYH10 抗体

目录号	产品名	应用	反应物种
HY-P83369	MYH10 Antibody (YA3114)	WB, IP	Human, Mouse
HY-P83369A	MYH10 Antibody (YA3114)(PBS only)	WB, IP	Human, Mouse

关联疾病

疾病名称

别名

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Coloboma, Ocular, Autosomal Dominant

Coloboma, Ocular	Coloboma Of Iris, Choroid, And Retina
Coi	Coloboma, Uveoretinal
COAD	Ocular Coloboma
Uveoretinal Coloboma	Chronic Obstructive Airway Disease

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Myh-9 Related Disease

Myh9-Related Disease	Myh9-Rd
Myh9-Related Disorder	Myh9-Related Syndrome
Myh9-Related Syndromic Thrombocytopenia	Sebastian Syndrome

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Deafness, Autosomal Dominant 17

DFNA17	Autosomal Dominant Nonsyndromic Deafness 17
Deafness, Autosomal Dominant Nonsyndromic Sensorineural 17	Autosomal Dominant Deafness 17
Late-Onset Progressive Hereditary Hearing Impairment Due To Cochleosaccular Degeneration	Nonsyndromic Hereditary Deafness Dfna17
Deafness, Autosomal Dominant, 17	Cochleosaccular Degeneration
Deafness, Autosomal Dominant, Type 17	Cochleosaccular Degeneration Of The Inner Ear And Progressive Cataracts

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08896	MYH10 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22660	Myh10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MYH10	VGNC	VGNC:43535
Felis catus	MYH10	VGNC	VGNC:68379
Bos taurus	MYH10	VGNC	VGNC:31794
Rattus norvegicus	MYH10	RGD	RGD:71000
Macaca mulatta	MYH10	VGNC	VGNC:99175
Mus musculus	MYH10	MGD	MGI:1930780

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MYH10 - myosin heavy chain 10 Gene

关于 MYH10

功能概要

MYH10 基因产物(4)

MYH10 蛋白结构

MYH10 抗体

关联疾病

直系同源

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MYH10 - myosin heavy chain 10 Gene

关于 MYH10

功能概要

MYH10 基因产物(4)

MYH10 蛋白结构

MYH10 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z