2. Gene
  3. PCYOX1 - prenylcysteine oxidase 1 Gene

PCYOX1 - prenylcysteine oxidase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：异戊二烯半胱氨酸氧化酶 1

种属: Homo sapiens

同用名: PCL1

基因 ID: 51449 | 基因类型: protein coding

关于 PCYOX1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,257,915-70,281,185 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues.

功能概要

异戊二烯化蛋白质降解过程中会释放异戊二烯半胱氨酸。 PCYOX1 催化异戊二烯半胱氨酸降解产生游离半胱氨酸和疏水类异戊二烯产物 (Tschantz 等人，1999 [PubMed 10585463]) 。[OMIM 提供，2008 年 3 月]

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

PCYOX1 基因产物(1)

mRNA Protein Name
NM_016297.4 NP_057381.3 prenylcysteine oxidase 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD binding IDA
IDA: 通过直接分析推断
11078725 GOA
enables prenylcysteine oxidase activity IDA
IDA: 通过直接分析推断
10585463 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in prenylated protein catabolic process IDA
IDA: 通过直接分析推断
10585463 GOA
involved in prenylcysteine catabolic process IDA
IDA: 通过直接分析推断
11078725 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosome IDA
IDA: 通过直接分析推断
10585463 GOA
part of very-low-density lipoprotein particle IDA
IDA: 通过直接分析推断
17154273 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCYOX1 蛋白结构

NAD_binding_8

NAD_binding_8: NAD(P)-binding Rossmann-like domain (39 - 106)

Prenylcys_lyase

Prenylcys_lyase: Prenylcysteine lyase (128 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

prenylcysteine oxidase 1

prenylcysteine lyase

关联疾病

疾病名称 别名
Coenzyme Q10 Deficiency, Primary, 9

COQ10D9

Primary Coenzyme Q10 Deficiency 9
Developmental And Epileptic Encephalopathy 33

DEE33

Epileptic Encephalopathy, Early Infantile, 33

Eiee33

Developmental And Epileptic Encephalopathy, 33

Early Infantile Epileptic Encephalopathy 33

Encephalopathy, Epileptic, Early Infantile, Type 33
Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency

IMD50

Immunodeficiency 50, X-Linked Recessive

Cid Due To Moesin Deficiency

Msn-Related Combined Immunodeficiency

X-Linked Moesin-Associated Immunodeficiency

Immunodeficiency 50 X Linked Recessive
Charcot-Marie-Tooth Disease, Axonal, Type 2cc

Charcot-Marie-Tooth Disease Axonal Type 2cc

CMT2CC

Charcot-Marie-Tooth Neuropathy, Type 2cc

Charcot-Marie-Tooth Neuropathy Type 2cc

Charcot-Marie-Tooth Disease 2cc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10179 PCYOX1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PCYOX1 VGNC VGNC:44327
Rattus norvegicus PCYOX1 RGD RGD:628652
Bos taurus PCYOX1 VGNC VGNC:32650
Macaca mulatta PCYOX1 VGNC VGNC:75658
Mus musculus PCYOX1 MGD MGI:1914131
Felis catus PCYOX1 VGNC VGNC:64074
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z