2. Gene
  3. ACOT13 - acyl-CoA thioesterase 13 Gene

ACOT13 - acyl-CoA thioesterase 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酰基辅酶 A 硫酯酶 13

种属: Homo sapiens

同用名: HT012; THEM2; PNAS-27

基因 ID: 55856 | 基因类型: protein coding

关于 ACOT13

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,667,077-24,705,046 (from NCBI)

This gene has 3 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 18.3), liver (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码硫酯酶超家族的一个成员。在人类中，该蛋白质与微管共定位，对持续的细胞增殖至关重要。同源小鼠蛋白形成同源四聚体并与线粒体相关。小鼠蛋白作为中链和长链酰基辅酶 A 硫酯酶发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 5 月]

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

ACOT13 基因产物(2)

mRNA Protein Name
NM_001160094.2 NP_001153566.1 acyl-coenzyme A thioesterase 13 isoform 2
NM_018473.4 NP_060943.1 acyl-coenzyme A thioesterase 13 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acyl-CoA hydrolase activity IDA
IDA: 通过直接分析推断
16934754 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein homotetramerization IPI
IPI: 通过物理相互作用推断
16934754 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACOT13 蛋白结构

4HBT

4HBT: Thioesterase superfamily (53 - 126)

  • 0
  • 100
  • 140 a.a.
蛋白主名 其他名称

acyl-coenzyme A thioesterase 13

hotdog-fold thioesterase superfamily member 2

ACOT13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
ACOT13 Q9NPJ3 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
种属内
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
种属内
ACOT13 Q9NPJ3 KAT5 Homo sapiens Q92993
Y2H Array
32814053
种属内
ACOT13 Q9NPJ3 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
ACOT13 Q9NPJ3 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ACOT13 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7452 ACOT13 Protein, Human (HEK293, His) Q9NPJ3-1 (T2-N140) ≥ 95%, as determined by reducing SDS-PAGE.

关联疾病

疾病名称 别名
Dyslexia
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00176 ACOT13 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19497 Acot13 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25991 Acot13 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ACOT13 VGNC VGNC:37518
Macaca mulatta ACOT13 VGNC VGNC:69487
Mus musculus ACOT13 MGD MGI:1914084
Bos taurus ACOT13 VGNC VGNC:25549
Felis catus ACOT13 VGNC VGNC:102373
Rattus norvegicus ACOT13 RGD RGD:1306513
Others ACOT13 NCBI
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