2. Gene
  3. Kcnip3 - Kv channel interacting protein 3, calsenilin Gene

Kcnip3 - Kv channel interacting protein 3, calsenilin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Csen; DREAM; KChIP3; 4933407H12Rik

基因 ID: 56461 | 基因类型: protein coding

关于 Kcnip3

功能概要

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding activity; and transcription cis-regulatory region binding activity. Involved in protein localization to plasma membrane; regulation of potassium ion transmembrane transport; and response to magnesium ion. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of transcription by RNA polymerase II; and sensory perception of pain. Located in cytosol and nucleus. Part of protein-DNA complex and voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and spinal cord. Orthologous to human KCNIP3 (potassium voltage-gated channel interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnip3 基因产物(3)

mRNA Protein Name
NM_001111331.1 NP_001104801.1 calsenilin isoform b precursor
NM_001291005.1 NP_001277934.1 calsenilin isoform c
NM_019789.4 NP_062763.2 calsenilin isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11792319 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11792319 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
11792319 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11792319 MGI
enables calcium ion binding IMP
IMP: 通过突变表型推断
15746104 MGI
enables calcium ion binding IPI
IPI: 通过物理相互作用推断
15746104 MGI
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
15746104 MGI
enables core promoter sequence-specific DNA binding IMP
IMP: 通过突变表型推断
15746104 MGI
enables magnesium ion binding IMP
IMP: 通过突变表型推断
15746104 MGI
enables magnesium ion binding IPI
IPI: 通过物理相互作用推断
15746104 MGI
enables potassium channel regulator activity IMP
IMP: 通过突变表型推断
20943905 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17189291 MGI
enables protein homodimerization activity EXP
EXP: 通过实验结果推断
15746104 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral response to pain IMP
IMP: 通过突变表型推断
14534243 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11792319 MGI
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
22311982 MGI
acts upstream of or within regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
17189291 MGI
involved in regulation of potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
20943905 MGI
involved in response to magnesium ion IMP
IMP: 通过突变表型推断
15746104 MGI
acts upstream of or within response to pain IMP
IMP: 通过突变表型推断
11792319 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
11792319 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17189291 MGI
located in nucleus IDA
IDA: 通过直接分析推断
17189291 MGI
part of protein-DNA complex IMP
IMP: 通过突变表型推断
15746104 MGI
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
19713751 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calsenilin

A-type potassium channel modulatory protein 3

DRE-antagonist modulator

calsenilin, presenilin binding protein, EF hand transcription factor

calsenilin/KChIP3 T+

calsenilin/KChIP3 T-

downstream regulatory element antagonist T+

downstream regulatory e

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07134 KCNIP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20559 Kcnip3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27068 Kcnip3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kcnip3 NCBI NCBI:30818
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