2. Gene
  3. RTN1 - reticulon 1 Gene

RTN1 - reticulon 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：网状 1

种属: Homo sapiens

同用名: NSP

基因 ID: 6252 | 基因类型: protein coding

关于 RTN1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,595,976-59,870,776 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 4 paralogues. Biased expression in brain (RPKM 96.0) and spleen (RPKM 6.9).

功能概要

该基因属于网状编码基因家族。网状细胞与内质网有关，并参与神经内分泌分泌或神经内分泌细胞的膜运输。该基因被认为是神经系统疾病和癌症的特异性标记，是治疗的潜在分子靶点。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 7 月]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and Cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

RTN1 基因产物(3)

mRNA Protein Name
NM_001363702.1 NP_001350631.1 reticulon-1 isoform D
NM_021136.3 NP_066959.1 reticulon-1 isoform A
NM_206852.3 NP_996734.1 reticulon-1 isoform C
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12873973 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of amyloid-beta formation IDA
IDA: 通过直接分析推断
15286784 GOA
involved in neuron differentiation IEP
IEP: 通过表达模式推断
9560466 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
12873973 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12873973 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
17684057 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RTN1 蛋白结构

Reticulon

Reticulon: Reticulon (590 - 758)

  • 0
  • 200
  • 400
  • 600
  • 776 a.a.
蛋白主名 其他名称

reticulon-1

neuroendocrine-specific protein

RTN1 抗体

目录号 产品名 应用 反应物种
HY-P89622 Rtn-1A/B Antibody (YA8966) WB, ICC/IF, IF-Tissue, FC, IP human

关联疾病

疾病名称 别名
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12329 RTN1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RTN1 VGNC VGNC:64810
Canis familiaris RTN1 VGNC VGNC:51680
Mus musculus RTN1 MGD MGI:1933947
Bos taurus RTN1 VGNC VGNC:34203
Rattus norvegicus RTN1 RGD RGD:620986
Macaca mulatta RTN1 VGNC VGNC:84762
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