2. Gene
  3. Tmprss6 - transmembrane serine protease 6 Gene

Tmprss6 - transmembrane serine protease 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 1300008A22Rik

基因 ID: 71753 | 基因类型: protein coding

关于 Tmprss6

功能概要

Predicted to enable serine-type endopeptidase activity. Involved in cellular iron ion homeostasis; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within iron ion homeostasis and negative regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including cerebral cortex; gut; hemolymphoid system gland; sensory organ; and uterus. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6). [provided by Alliance of Genome Resources, Apr 2022]

Tmprss6 基因产物(2)

mRNA Protein Name
NM_001355601.1 NP_001342530.1 transmembrane protease serine 6 isoform 2
NM_027902.2 NP_082178.2 transmembrane protease serine 6 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19751239 MGI
involved in intracellular iron ion homeostasis IMP
IMP: 通过突变表型推断
25860887 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
19751239 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19751239 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25860887 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25860887 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12744720 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transmembrane protease serine 6

matriptase 2

transmembrane protease, serine 6

type II transmembrane serine protease 6

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-177662 Sapablursen Inhibitor 96.05% Phase 2
HY-177662A Sapablursen sodium Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-130136A TMPRSS6-IN-1 TFA Inhibitor / 否
HY-130136 TMPRSS6-IN-1 Inhibitor / 否
HY-147278 Manusiran Inhibitor / 否
HY-147278A Manusiran sodium Inhibitor / 否
HY-P11260 MD5 Inhibitor / 否
HY-RS14773 TMPRSS6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-180217 WGU55 Inhibitor / 否
HY-RS19286 Tmprss6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25776 Tmprss6 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991137 Exerenibart Inhibitor / 否
HY-P991637 REGN7999 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tmprss6 NCBI NCBI:164656
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