2. Gene
  3. Kdm5b - lysine (K)-specific demethylase 5B Gene

Kdm5b - lysine (K)-specific demethylase 5B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PUT1; Plu1; PLU-1; Rb-Bp2; Jarid1b; RBBP2H1A; mKIAA4034; D1Ertd202e; 2010009J12Rik; 2210016I17Rik

基因 ID: 75605 | 基因类型: protein coding

关于 Kdm5b

功能概要

This gene encodes a lysine-specific Histone Demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain Cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]

Kdm5b 基因产物(1)

mRNA Protein Name
NM_152895.2 NP_690855.2 lysine-specific demethylase 5B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3K4 demethylase activity IDA
IDA: 通过直接分析推断
17320160 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21448134 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
24802759 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: 通过突变表型推断
24802759 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21960634 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
24802759 MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
24802759 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
24802759 MGI
acts upstream of or within regulation of estradiol secretion IMP
IMP: 通过突变表型推断
24802759 MGI
acts upstream of or within single fertilization IMP
IMP: 通过突变表型推断
24802759 MGI
acts upstream of or within uterus morphogenesis IMP
IMP: 通过突变表型推断
24802759 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lysine-specific demethylase 5B

[histone H3]-trimethyl-L-lysine(4) demethylase 5B

histone demethylase JARID1B

jumonji, AT rich interactive domain 1B (Rbp2 like)

jumonji/ARID domain-containing protein 1B

putative DNA/chromatin binding motif 1

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-104048 QC6352 Inhibitor 99.13% 否
HY-116761 GSK467 Inhibitor 99.34% 否
HY-100744 AS8351 Inhibitor 99.88% 否
HY-102047B KDOAM-25 citrate Inhibitor 98.56% 否
HY-151483 TK-129 Inhibitor ≥98.0% 否
HY-100014 KDM5A-IN-1 Inhibitor 99.64% 否
HY-119397A KDM5-C49 hydrochloride Inhibitor 98.22% 否
HY-101451 PBIT Inhibitor 99.46% 否
HY-149091 KDM5B-IN-4 Inhibitor 99.68% 否
HY-158432 GT-653 Degrader 99.84% 否
HY-100764 YUKA1 Inhibitor 99.15% 否
HY-RS07219 KDM5B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-102047 KDOAM-25 Inhibitor / 否
HY-128343 KDM4-IN-2 Inhibitor 98.29% 否
HY-102047A KDOAM-25 trihydrochloride Inhibitor / 否
HY-119397 KDM5-C49 Inhibitor / 否
HY-146670 KDM5B-IN-3 Inhibitor / 否
HY-158433 KDM5B ligand 2 / 否
HY-175036 YTHu78 / 否
HY-RS16636 Kdm5b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23071 Kdm5b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kdm5b NCBI NCBI:10765
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