1. Gene
  2. GRWD1 - glutamate rich WD repeat containing 1 Gene

GRWD1 - glutamate rich WD repeat containing 1 Gene

中文名称:含富谷氨酸的 WD 重复 1

种属: Homo sapiens

同用名: CDW4; GRWD; RRB1; WDR28

基因 ID: 83743 | 基因类型: protein coding

关于 GRWD1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,445,983-48,457,022 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 9 paralogues. Ubiquitous expression in placenta (RPKM 6.8), appendix (RPKM 6.7) and 25 other tissues.

功能概要

该基因编码一种富含谷氨酸的蛋白质,其中包含五个 WD 重复基序。编码的蛋白质可能在核糖体生物合成中发挥关键作用,也可能通过与 CUL4-DDB1 泛素 E3 连接酶的相互作用在组蛋白甲基化中发挥作用。[RefSeq 提供,2012 年 2 月]

This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 Ligase. [provided by RefSeq, Feb 2012]

GRWD1 基因产物(1)

mRNA Protein Name
NM_031485.4 NP_113673.3 glutamate-rich WD repeat-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA replication origin binding IDA
IDA: 通过直接分析推断
25990725 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
25990725 GOA
enables histone binding IDA
IDA: 通过直接分析推断
25990725 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17041588 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication IMP
IMP: 通过突变表型推断
25990725 GOA
involved in nucleosome assembly IDA
IDA: 通过直接分析推断
25990725 GOA
involved in nucleosome assembly IMP
IMP: 通过突变表型推断
27552915 GOA
involved in nucleosome disassembly IMP
IMP: 通过突变表型推断
27552915 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
25990725 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23349634 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GRWD1 蛋白结构

CAF1C_H4-bd

CAF1C_H4-bd: Histone-binding protein RBBP4 or subunit C of CAF1 complex (43 - 112)

WD40

WD40: WD domain, G-beta repeat (257 - 290)

WD40

WD40: WD domain, G-beta repeat (302 - 336)

WD40

WD40: WD domain, G-beta repeat (343 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
蛋白主名 其他名称

glutamate-rich WD repeat-containing protein 1

CUL4- and DDB1-associated WDR protein 4

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GRWD1 VGNC VGNC:73213
Bos taurus GRWD1 VGNC VGNC:29669
Canis familiaris GRWD1 VGNC VGNC:41521
Rattus norvegicus GRWD1 RGD RGD:1310649
Felis catus GRWD1 VGNC VGNC:62722
Mus musculus GRWD1 MGD MGI:2141989