2. 多肽产品
  3. 多肽及其衍生物
  4. GPLGVRG

GPLGVRG 是一种响应 MMP13 的连接肽。GPLGVRG 可被 MMP13 水解，进而触发胶束解体、两亲性丧失，并提高相关递送系统的软骨细胞摄取率。GPLGVRG 可用于骨关节炎的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

GPLGVRG

GPLGVRG Chemical Structure

CAS No. : 915404-04-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GPLGVRG:

GPLGVRG 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPLGVRG is an MMP13-responsive linker peptide. GPLGVRG can be hydrolyzed by MMP13, which in turn triggers micellar disintegration, loss of amphipathicity, and increases the chondrocyte uptake rate of the related delivery system. GPLGVRG can be used in the research of osteoarthritis[1].

IC50 & Target[1]

MMP13

 

体外研究
(In Vitro)

GPLGVRG peptide 可被 IL-1β 刺激的骨关节炎 (OA) 软骨细胞中存在的 MMP13 选择性切割，通过 FRET 底物切割产生可检测的荧光信号，该信号可被 MMP 抑制剂抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPLGVRG 相关抗体:
体内研究
(In Vivo)

含 GPLGVRG 的 Mic-Exo (胶束：外泌体蛋白质量比 10:1；250 μM DHA；关节腔内给药；单次给药) 是一种 MMP 响应性、可穿透软骨的递送系统，能够将 DHA (HY-B2167) 靶向递送至 OA 骨细胞，可显著延缓大鼠 OA 的进展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 12 weeks old, 300 to 350 g, ACLT+DMM induced knee OA)[1]
Dosage: micelle:exosome protein mass ratio 10:1; 250 μM DHA
Administration: intra-articular; single dose
Result: Reduced Osteoarthritis Research Society International.
Preserved cartilage thickness.
Increased chondrocyte number.
Reduced positive staining for ADAMTS5 to 17.0% versus 79.3% in OA control.
Reduced positive staining for MMP13 to 14.7% versus 72.1% in OA control.
Increased trabecular bone mineral density to 1.4 versus 1.3 in OA control.
Increased trabecular thickness to 0.2 mm versus 0.1 mm in OA control.
Increased bone volume fraction to 45.2% versus 33.9% in OA control.
Penetrated ex vivo rat femoral head cartilage to 74.0 μm versus 32.4 μm for unmodified exosomes at 48 h.
Penetrated ex vivo rat femoral head cartilage to 155.0 μm versus 36.3 μm for unmodified exosomes at 72 h.
分子量

654.76

Formula

C28H50N10O8
CAS 号
Sequence

Gly-Pro-Leu-Gly-Val-Arg-Gly
Sequence Shortening

GPLGVRG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPLGVRG 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPLGVRG915404-04-5beaglesIL-1β-stimulated human OA chondrocytesMMP13human OA cartilageratsosteoarthritisnormal human chondrocyteschondrocytesubchondral bonecartilageInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GPLGVRG
目录号：
HY-P11800
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z